Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta-analysis

IF 4.6 2区医学 Q2 ALLERGY

Clinical and Translational Allergy Pub Date : 2024-03-15 DOI:10.1002/clt2.12346

Yuan Ai, Jichong Huang, Ting Ting Zhu

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Abstract

Background

The incidence of atopic dermatitis (AD) in children is increasing. Early exposure to stress factors may be associated with the AD development. This study aimed to summarize studies that reported an association between stress exposure and AD development in later life.

Methods and findings

A comprehensive literature search was performed using online databases (PubMed, EMBASE, PsycINFO, and Web of Science) for articles published up to May 1, 2023. Eligible studies were screened and selected based on the inclusion criteria. We incorporated cohort or case-control studies published in English which explored the relationship between stress experienced by parents or children and AD. The pooled odds ratio (OR) was calculated according to the type of stress using a random-effects model. Twenty-two studies were included. AD was related to maternal distress (OR 1.29, 95% Confidence Interval [CI]: 1.13–1.47), maternal anxiety (OR 1.31, 95% CI: 1.18–1.46), and negative life events (OR 2.00, 95% CI: 1.46–2.76). Maternal depression during pregnancy was associated with AD (OR 1.21, 95% CI: 1.09–1.33), whereas no significant association was found for postpartum depression. Research on stress experienced by paternal or children is scare.

Conclusions

Early maternal stress may potentially elevate the risk of AD in their offspring. Importantly, rigorously designed studies are required to corroborate the link between maternal stress and AD in children. These studies should aim to gather insights about the impact of stress during specific trimesters of pregnancy, postnatal stress, and paternal stress, and to identify potential prevention strategies.

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早期接触母亲压力与儿童患特应性皮炎的风险：系统回顾和荟萃分析。

背景：儿童特应性皮炎（AD）的发病率正在上升。早期暴露于压力因素可能与特应性皮炎的发展有关。本研究旨在总结报告压力暴露与特应性皮炎晚期发展之间关系的研究：我们使用在线数据库（PubMed、EMBASE、PsycINFO 和 Web of Science）对截至 2023 年 5 月 1 日发表的文章进行了全面的文献检索。根据纳入标准对符合条件的研究进行了筛选。我们纳入了以英语发表的队列研究或病例对照研究，这些研究探讨了父母或子女所经历的压力与注意力缺失症之间的关系。采用随机效应模型，根据压力类型计算汇总的几率比（OR）。共纳入 22 项研究。注意力缺失与孕产妇痛苦（OR 1.29，95% 置信区间[CI]：1.13-1.47）、孕产妇焦虑（OR 1.31，95% 置信区间：1.18-1.46）和负面生活事件（OR 2.00，95% 置信区间：1.46-2.76）有关。孕期母亲抑郁与注意力缺失症相关（OR 1.21，95% CI：1.09-1.33），而产后抑郁与注意力缺失症无明显关联。有关父亲或子女所经历的压力的研究尚不充分：结论：母亲的早期压力可能会增加其后代罹患注意力缺失症的风险。重要的是，需要进行严格设计的研究来证实母亲压力与儿童注意力缺失症之间的联系。这些研究的目的应该是了解特定孕期压力、产后压力和父亲压力的影响，并确定潜在的预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.