Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma

IF 3.7 3区医学 Q2 ALLERGY

Journal of Asthma and Allergy Pub Date : 2024-03-15 DOI:10.2147/jaa.s451725

Ting-Yu Lin, Firdian Makrufardi, Nguyen Thanh Tung, Amja Manullang, Po-Jui Chang, Chun-Yu Lo, Tzu-Hsuan Chiu, Pi-Hung Tung, Chiung-Hung Lin, Horng-Chyuan Lin, Chun-Hua Wang, Shu-Min Lin

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引用次数: 0

Abstract

Background: Early-onset asthma (EOA) and late-onset asthma (LOA) are two distinct phenotypes. Air pollution has been associated with an increase in poorer asthma outcomes. The objective of this study was to examine the effects of traffic-related air pollution (TRAP) on asthma outcomes in EOA and LOA patients.
Methods: A cross-sectional study was conducted on 675 asthma patients (LOA: 415) recruited from a major medical center in Taiwan. The land-use regression (LUR) model was used to estimate the level of exposure to PM₁₀, PM_2.5, NO₂, and O₃ on an individual level. We investigated the association between TRAP and asthma outcomes in EOA and LOA patients, stratified by allergic sensitization status, using a regression approach.
Results: An increase in PM₁₀ was associated with younger age of onset, increased asthma duration, and decreased lung function in EOA patients (p< 0.05). An increase in PM₁₀ was associated with older age of onset, and decreased asthma duration, eosinophil count, and Asthma Control Test (ACT) score in LOA patients. An increase in PM_2.5 was associated with younger age of onset, increased asthma duration, decreased eosinophil count, and lung function in EOA patients (p< 0.05). An increase in PM_2.5 was associated with decreased lung function and ACT score in LOA patients. An increase in NO₂ was associated with increased eosinophil count and decreased lung function in EOA patients (p< 0.05). An increase in O₃ was associated with decreased lung function in LOA patients (p< 0.05). In addition, associations of TRAP with age of onset and eosinophil counts were mainly observed in both EOA and LOA patients with allergic sensitization, and an association with ACT was mainly observed in LOA patients without allergic sensitization.
Conclusion: The impact of TRAP on age of onset, eosinophil count, and lung function in EOA patients, and ACT in LOA patients, was affected by the status of allergic sensitization.

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交通相关空气污染对早发和晚发哮喘的不同影响

背景：早发哮喘（EOA）和晚发哮喘（LOA）是两种不同的表型。空气污染与较差哮喘结果的增加有关。本研究旨在探讨交通相关空气污染（TRAP）对 EOA 和 LOA 患者哮喘预后的影响：方法：本研究对从台湾一家大型医疗中心招募的 675 名哮喘患者（LOA：415 名）进行了横断面研究。研究采用土地利用回归（LUR）模型来估算个人暴露于 PM10、PM2.5、NO2 和 O3 的水平。我们采用回归法研究了EOA和LOA患者的TRAP与哮喘结果之间的关系，并按过敏致敏状态进行了分层：结果：在 EOA 患者中，PM10 的增加与发病年龄的降低、哮喘持续时间的延长和肺功能的下降有关（p< 0.05）。PM10 的增加与 LOA 患者的发病年龄增大、哮喘持续时间缩短、嗜酸性粒细胞计数和哮喘控制测试（ACT）得分降低有关。PM2.5 的增加与 EOA 患者的发病年龄较小、哮喘持续时间延长、嗜酸性粒细胞计数减少和肺功能相关（p< 0.05）。PM2.5的增加与LOA患者肺功能和ACT评分的下降有关。NO2 的增加与 EOA 患者的嗜酸性粒细胞计数增加和肺功能下降有关（p< 0.05）。O3 的增加与 LOA 患者肺功能的下降有关（p< 0.05）。此外，TRAP与发病年龄和嗜酸性粒细胞计数的关系主要出现在有过敏致敏现象的EOA和LOA患者中，而与ACT的关系主要出现在无过敏致敏现象的LOA患者中：结论：TRAP对EOA患者的发病年龄、嗜酸性粒细胞计数和肺功能以及对LOA患者的ACT的影响受过敏致敏状态的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.