{"title":"Continuous Flow Chemistry with Solids: A Review","authors":"Hannah L. D. Hayes*, and , Carl J. Mallia, ","doi":"10.1021/acs.oprd.3c00407","DOIUrl":null,"url":null,"abstract":"<p >The effective handling of solids in a continuous flow process is one of the biggest perceived challenges remaining for modern flow chemistry. This Review aims to consider some of the continuous processes for chemistries involving solids which have been successfully implemented. Learnings from the design of these systems, and identification of the common blockers, will guide a generalized, strategic approach to drive the efficiency of future batch-to-flow development for challenging, heterogeneous systems. Assorted techniques for managing solids in continuous-flow synthesis will be presented herein through a series of case studies, and broken down into several key categories; solubility considerations, setup components and modularity, applications of ultrasonication, reactor type and continuous Grignard reactions.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Process Research & Development","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.oprd.3c00407","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
The effective handling of solids in a continuous flow process is one of the biggest perceived challenges remaining for modern flow chemistry. This Review aims to consider some of the continuous processes for chemistries involving solids which have been successfully implemented. Learnings from the design of these systems, and identification of the common blockers, will guide a generalized, strategic approach to drive the efficiency of future batch-to-flow development for challenging, heterogeneous systems. Assorted techniques for managing solids in continuous-flow synthesis will be presented herein through a series of case studies, and broken down into several key categories; solubility considerations, setup components and modularity, applications of ultrasonication, reactor type and continuous Grignard reactions.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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