Can the neural representation of physical pain predict empathy for pain in others?

M Li, C Racey, C L Rae, W Strawson, H D Critchley, J Ward
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Abstract

The question of whether physical pain and vicarious pain have some shared neural substrates is unresolved. Recent research has argued that physical and vicarious pain are represented by dissociable multivariate brain patterns by creating biomarkers for physical pain (Neurologic Pain Signature, NPS) and vicarious pain (Vicarious Pain Signature, VPS), respectively. In the current research, the NPS and two versions of the VPS were applied to three fMRI datasets (one new, two published) relating to vicarious pain which focused on between-subject differences in vicarious pain (Datasets 1 and 3) and within-subject manipulations of perspective taking (Dataset 2). Results show that (i) NPS can distinguish brain responses to images of pain vs no-pain and to a greater extent in vicarious pain responders who report experiencing pain when observing pain and (ii) neither version of the VPS mapped on to individual differences in vicarious pain and the two versions differed in their success in predicting vicarious pain overall. This study suggests that the NPS (created to detect physical pain) is, under some circumstances, sensitive to vicarious pain and there is significant variability in VPS measures (created to detect vicarious pain) to act as generalizable biomarkers of vicarious pain.

身体疼痛的神经表征能否预测对他人疼痛的同情?
身体疼痛和替代疼痛是否有一些共同的神经基质,这个问题尚未解决。最近的研究认为,通过分别创建身体疼痛(神经疼痛特征,NPS)和替代疼痛(替代疼痛特征,VPS)的生物标记,身体疼痛和替代疼痛由可分离的多变量大脑模式表示。在当前的研究中,NPS 和两个版本的 VPS 被应用于三个与替代性疼痛相关的 fMRI 数据集(一个新数据集,两个已发表数据集),重点研究替代性疼痛的受试者间差异(数据集 1 和 3)和受试者内透视法操作(数据集 2)。结果表明:(1) NPS 可以区分大脑对疼痛图像和无疼痛图像的反应,并在更大程度上区分那些报告在观察疼痛时经历过疼痛的替代疼痛反应者;(2) 两个版本的 VPS 都不能反映替代疼痛的个体差异,而且两个版本在预测总体替代疼痛方面的成功率不同。这项研究表明,在某些情况下,NPS(用于检测身体疼痛)对替代性疼痛很敏感,而 VPS 测量(用于检测替代性疼痛)在作为替代性疼痛的通用生物标志物方面存在显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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