Wound healing outcomes following treatment with synthetic hybrid-scale fiber matrix after resection of soft tissue tumors or infections.

IF 1.4 4区医学 Q3 DERMATOLOGY

Wounds : a compendium of clinical research and practice Pub Date : 2024-02-01

Bennie Lindeque, Daniel Moon

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引用次数: 0

Abstract

Background: Wide excision of soft tissue tumors or infections often results in large defects that can be challenging to manage. Advanced treatment modalities-including NPWT, skin grafts, and xenografts-can all be considered for post-resection wound management, but each has its limitations. An SHSFM, engineered to resemble human extracellular matrix, has demonstrated positive wound healing outcomes in prior studies.

Materials and methods: Adult patients at a single institution who underwent resection of soft tissue tumor or infected tissue followed by treatment with SHSFM from 2020-2023 were retrospectively reviewed.

Results: Ten patients were included in the review after meeting the inclusion criteria. Overall, 7 of 10 wounds had documented complete closure, with 3 lost to follow-up. Average time to wound closure was 119 days. Patients either healed via secondary intention or were bridged to a split-thickness skin graft. The average VSS score was 3.3 when assessed.

Conclusion: The current case series demonstrated that the SHSFM can support granulation tissue formation over exposed structures as a bridge to skin graft or can completely reepithelialize large wounds without skin grafting. The SHSFM offers a novel treatment option for post-resection surgical wounds.

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软组织肿瘤或感染切除术后使用合成杂化纤维基质治疗后的伤口愈合效果。

背景：大面积切除软组织肿瘤或感染往往会造成大面积缺损，这对伤口的处理是一个挑战。先进的治疗方法--包括NPWT、皮肤移植和异种移植--都可用于切除术后的伤口管理，但每种方法都有其局限性。在之前的研究中，一种类似于人类细胞外基质的 SHSFM 已显示出积极的伤口愈合效果：回顾性研究了 2020-2023 年间在一家医疗机构接受软组织肿瘤或感染组织切除术并接受 SHSFM 治疗的成人患者：符合纳入标准的 10 例患者被纳入回顾性研究。总体而言，10 例患者中有 7 例伤口完全闭合，3 例失去随访记录。伤口愈合的平均时间为 119 天。患者要么通过二次意向愈合，要么通过分层厚皮移植进行桥接。评估时的平均 VSS 得分为 3.3：目前的病例系列表明，SHSFM 可以支持肉芽组织在暴露结构上形成，作为植皮的桥梁，也可以在不植皮的情况下使大面积伤口完全再上皮化。SHSFM为切除手术后的伤口提供了一种新的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.