Perfusion imaging by arterial spin labeling in migraine: A literature review.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-14 DOI:10.1177/0271678X241237733

Severin Schramm, Corinna Börner, Miriam Reichert, Gabriel Hoffmann, Stephan Kaczmarz, Michael Griessmair, Kirsten Jung, Maria T Berndt, Claus Zimmer, Thomas Baum, Florian Heinen, Michaela V Bonfert, Nico Sollmann

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引用次数: 0

Abstract

Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method for the assessment of cerebral blood flow (CBF). This review summarizes recent ASL-based investigations in adult and pediatric patients with migraine with aura, migraine without aura, and chronic migraine. A systematic search according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted within PubMed and reference sections of articles identified from April 2014 to November 2022. Out of 236 initial articles, 20 remained after filtering, encompassing data from 1155 subjects in total. Cross-sectional studies in adults showed inconsistent results, while longitudinal studies demonstrated that cerebral perfusion changes over the migraine cycle can be tracked using ASL. The most consistent findings were observed in ictal states among pediatric migraine patients, where studies showed hypoperfusion matching aura symptoms during early imaging followed by hyperperfusion. Overall, ASL is a useful but currently underutilized modality for evaluating cerebral perfusion in patients with migraine. The generalizability of results is currently limited by heterogeneities regarding study design and documentation of clinical variables (e.g., relation of attacks to scanning timepoint, migraine subtypes). Future MRI studies should consider augmenting imaging protocols with ASL to further elucidate perfusion dynamics in migraine.

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偏头痛的动脉自旋标记灌注成像：文献综述。

动脉自旋标记（ASL）是一种评估脑血流（CBF）的无创磁共振成像（MRI）方法。本综述总结了近期对先兆偏头痛、无先兆偏头痛和慢性偏头痛的成人和儿童患者进行的基于 ASL 的研究。根据系统综述和元分析首选报告项目（PRISMA）指南，在PubMed和参考文献中对2014年4月至2022年11月期间的文章进行了系统检索。在 236 篇初始文章中，经过筛选后保留了 20 篇，共包含 1155 名受试者的数据。成人横断面研究显示的结果并不一致，而纵向研究则表明，偏头痛周期内的脑灌注变化可通过 ASL 追踪。在小儿偏头痛患者的发作状态下观察到的结果最为一致，研究显示，在早期成像时，脑灌注不足与先兆症状相匹配，随后出现脑灌注亢进。总之，ASL 是评估偏头痛患者脑灌注情况的一种有用但目前未得到充分利用的方法。目前，研究设计和临床变量记录（如发作与扫描时间点的关系、偏头痛亚型）方面的异质性限制了研究结果的推广性。未来的 MRI 研究应考虑使用 ASL 增强成像方案，以进一步阐明偏头痛的灌注动态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.