Terahertz in vivo imaging of human skin: Toward detection of abnormal skin pathologies.

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL
APL Bioengineering Pub Date : 2024-03-11 eCollection Date: 2024-03-01 DOI:10.1063/5.0190573
X Qi, K Bertling, J Torniainen, F Kong, T Gillespie, C Primiero, M S Stark, P Dean, D Indjin, L H Li, E H Linfield, A G Davies, M Brünig, T Mills, C Rosendahl, H P Soyer, A D Rakić
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引用次数: 0

Abstract

Terahertz (THz) imaging has long held promise for skin cancer detection but has been hampered by the lack of practical technological implementation. In this article, we introduce a technique for discriminating several skin pathologies using a coherent THz confocal system based on a THz quantum cascade laser. High resolution in vivo THz images (with diffraction limited to the order of 100 μm) of several different lesion types were acquired and compared against one another using the amplitude and phase values. Our system successfully separated pathologies using a combination of phase and amplitude information and their respective surface textures. The large scan field (50 × 40 mm) of the system allows macroscopic visualization of several skin lesions in a single frame. Utilizing THz imaging for dermatological assessment of skin lesions offers substantial additional diagnostic value for clinicians. THz images contain information complementary to the information contained in the conventional digital images.

太赫兹人体皮肤活体成像:检测异常皮肤病变。
太赫兹(THz)成像技术在皮肤癌检测方面一直大有可为,但由于缺乏实际的技术实施而受到阻碍。在本文中,我们介绍了一种利用基于太赫兹量子级联激光器的相干太赫兹共焦系统分辨多种皮肤病变的技术。我们获取了几种不同病变类型的高分辨率活体太赫兹图像(衍射限制在 100 μm 量级),并利用振幅和相位值进行了相互比较。我们的系统结合了相位和振幅信息及其各自的表面纹理,成功地分离了病变。该系统的扫描范围大(50 × 40 毫米),可在一帧图像中对多个皮肤病变进行宏观观察。利用太赫兹成像技术对皮肤病变进行皮肤学评估,可为临床医生提供大量额外的诊断价值。太赫兹图像包含的信息是对传统数字图像所含信息的补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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