Serum adropin level in wet-type age-related macular degeneration.

IF 1.9 Q2 OPHTHALMOLOGY

International Journal of Retina and Vitreous Pub Date : 2024-03-12 DOI:10.1186/s40942-024-00543-7

Zahra Saeedi-Maleki, Alireza Javadzadeh, Fariborz Brumandpur, Amir Ghorbanihaghjo, Shokoufeh Khanzadeh, Farideh Mousavi

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引用次数: 0

Abstract

Purpose: Our objective was to compare the serum Adropin levels between patients with wet-type Age-Related Macular Degeneration (AMD) and otherwise healthy individuals.

Method: The study included 45 patients with wet-type AMD and 45 individuals without age-related macular degeneration. Patients with co-morbidities such as diabetes, hypertension, autoimmune diseases, and a previous history of visual impairment; were excluded. FBS, Hemoglobin A1C (HbA1C), lipid profile, and serum Adropin level were checked.

Results: The mean serum Adropin level of patients with wet-type AMD was significantly lower than the control group (P-value < 0.001). Also, the mean High-sensitivity C-reactive protein ( hsCRP) level and High Density Lipoprotein (HDL) were significantly higher in wet-type AMD patients (P-value = 0.031 and < 0.001 respectively).

Conclusions: In our study, wet-type AMD was associated with a lower level of serum Adropin. Because of Adropin involvement in glucose metabolism and age-related changes, it may have a role in the pathogenesis of AMD, but it requires more investigations at the molecular level to elucidate its function.

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湿型老年性黄斑变性的血清阿托品水平。

目的：我们的目的是比较湿性老年性黄斑变性（AMD）患者和其他健康人的血清阿托品水平：研究对象包括 45 名湿润型老年性黄斑变性患者和 45 名非老年性黄斑变性患者。排除合并糖尿病、高血压、自身免疫性疾病和既往视力损伤病史的患者。检查了血脂、血红蛋白 A1C (HbA1C)、血脂概况和血清 Adropin 水平：结果：湿性 AMD 患者的平均血清 Adropin 水平明显低于对照组（P 值结论：湿性 AMD 患者的平均血清 Adropin 水平明显低于对照组（P 值）：在我们的研究中，湿性AMD患者的血清Adropin水平较低。由于Adropin参与糖代谢和与年龄相关的变化，它可能在AMD的发病机制中发挥作用，但需要在分子水平上进行更多研究，以阐明其功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Retina and Vitreous Medicine-Ophthalmology

CiteScore

3.50

自引率

4.30%

发文量

审稿时长

19 weeks

期刊介绍： International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities