Network pharmacology and pharmacological evaluation of Wenzheng Jiedu Powder Modified Formula for neuropathic pain relief.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-01 DOI:10.4149/gpb_2023040

Yanping Li, Feng Yang, Wanying Lang, Qi An, Zhi Pan, Wenyu Shi, Xiaowei Shi

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引用次数: 0

Abstract

This study aimed to elucidate the mechanism of Wenzheng Jiedu Powder Modified Formula (WJPMF) in treating neuropathic pain (NP). Network pharmacology and experimental verification were integrated to explore the therapeutic effects and key targets of WJPMF. Active components, corresponding target genes, and absorption, distribution, metabolism, and excretion (ADME) genes of WJPMF against NP were screened from public databases. Network analysis and molecular docking were conducted to identify key targets and verify binding abilities. In vivo experiments were performed on spared nerve injury (SNI) rats to assess the analgesic effects and regulatory mechanisms of WJPMF. WJPMF significantly improved pain behaviors in SNI rats by regulating ATP-binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor alpha (PPARA), peroxisome proliferator-activated receptor gamma (PPARG), and superoxide dismutase 2 (SOD2) expression, which were key targets involved in the peroxisome proliferator-activated receptor (PPAR) signaling pathway. WJPMF shows promising therapeutic potential for NP through the modulation of specific targets, offering a novel therapeutic strategy for managing NP.

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缓解神经病理性疼痛的文正街杜粉改良方的网络药理学和药效学评价

本研究旨在阐明文正街杜粉（WJPMF）治疗神经病理性疼痛（NP）的机制。该研究将网络药理学和实验验证相结合，探讨了文正街杜粉的治疗作用和关键靶点。从公共数据库中筛选了 WJPMF 的活性成分、相应的靶基因以及针对 NP 的吸收、分布、代谢和排泄（ADME）基因。通过网络分析和分子对接来确定关键靶点并验证结合能力。对神经损伤（SNI）大鼠进行了体内实验，以评估 WJPMF 的镇痛效果和调控机制。WJPMF通过调节ATP结合盒转运体A1（ABCA1）、过氧化物酶体增殖激活受体α（PPARA）、过氧化物酶体增殖激活受体γ（PPARG）和超氧化物歧化酶2（SOD2）的表达，明显改善了SNI大鼠的疼痛行为。通过调节特定靶点，WJPMF 显示出治疗 NP 的巨大潜力，为治疗 NP 提供了一种新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.