Epicardial fat thickness among neonates of diabetic mothers attending the neonatal intensive care unit at Fayoum University Hospital: a case control study

IF 0.5 Q4 PEDIATRICS

Egyptian Pediatric Association Gazette Pub Date : 2024-03-12 DOI:10.1186/s43054-024-00254-6

Ahmed M. Abd El Moktader, Remon M. Yousef, Ahmed Safwat, Heba A. Borayek

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Abstract

Using conventional echocardiography, this study aimed to evaluate the epicardial fat thickness (EFT) and its role in discriminating infants of diabetic mothers (IDMs) from those of non-diabetic mothers (INDMs) and to assess its prognostic role in IDMs. This case control study was conducted at the Neonatology and Cardiology Units of Pediatric Department, Fayoum University Hospital, Egypt, between February and September 2023. A total of 54 neonates were enrolled into three groups: 18 IDMs with well-controlled diabetes mellitus (DM), 18 IDMs with poorly controlled DM, and 18 INDMs. The sensitivity, specificity, and cutoff of EFT were 100%, 100%, and 3.950 mm for detecting cases of IDMs and were 66.7%, 72.2%, and 5.100 mm for differentiating controlled from uncontrolled diabetic mothers, respectively. The interventricular septum in diastole (IVSd), interventricular septum in systole (IVSs), estimated pulmonary artery pressure (PAP), left ventricle (LV) Tei index, and isovolumetric relaxation time (IVRT) of LV all showed a positive correlation with EFT (r = 0.35, 0.31, 0.41, 0.34, and 0.39; P = 0.009, 0.025, 0.002, 0.01, and 0.003; respectively). There was a significant negative correlation between EFT and left ventricular internal dimensions in diastole (LVIDd) and left ventricular internal dimensions in systole (LVIDs) (r = − 0.44 and 0.42, P = 0.001 and 0.001). Regarding tissue Doppler, there was a significantly higher Tei index in group I cases compared to control (0.59 ± 0.10 vs. 0.49 ± 0.09, P < 0.001). The EFT is higher in IDMs than in INDMs, with a positive correlation with birth weight, IVSd, IVSs, Tei index of mitral, IVRT, and ESPAP and a negative correlation with LVIDd and LVIDs. Neonatal EFT can be used as one of the helpful parameters to detect IDMs. Also, it may be used as one of the prognostic factors in IDMs as it is positively correlated with the diastolic function of the LV.

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法尤姆大学医院新生儿重症监护室糖尿病母亲所生新生儿的心外膜脂肪厚度：病例对照研究

本研究旨在使用传统超声心动图评估心外膜脂肪厚度（EFT）及其在区分糖尿病母亲（IDM）和非糖尿病母亲（INDM）所生婴儿方面的作用，并评估其在 IDM 中的预后作用。这项病例对照研究于 2023 年 2 月至 9 月在埃及法尤姆大学医院儿科新生儿科和心脏病科进行。共有 54 名新生儿被分为三组：18 名糖尿病（DM）控制良好的 IDM、18 名糖尿病（DM）控制不佳的 IDM 和 18 名 INDM。EFT检测IDM病例的灵敏度、特异性和临界值分别为100%、100%和3.950毫米，区分糖尿病控制和未控制母亲的灵敏度、特异性和临界值分别为66.7%、72.2%和5.100毫米。舒张期室间隔（IVSd）、收缩期室间隔（IVSs）、估计肺动脉压（PAP）、左心室Tei指数和左心室等容舒张时间（IVRT）均与EFT呈正相关（r = 0.35、0.31、0.41、0.34 和 0.39；P = 0.009、0.025、0.002、0.01 和 0.003；）。EFT 与左心室舒张期内部尺寸（LVIDd）和左心室收缩期内部尺寸（LVIDs）之间存在明显的负相关（r = - 0.44 和 0.42，P = 0.001 和 0.001）。在组织多普勒方面，I组病例的Tei指数明显高于对照组（0.59 ± 0.10 vs. 0.49 ± 0.09，P < 0.001）。IDM的EFT高于INDM，与出生体重、IVSd、IVSs、二尖瓣Tei指数、IVRT和ESPAP呈正相关，与LVIDd和LVIDs呈负相关。新生儿 EFT 可作为检测 IDM 的有用参数之一。此外，EFT 与左心室舒张功能呈正相关，因此也可作为 IDM 的预后因素之一。

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来源期刊

Egyptian Pediatric Association Gazette PEDIATRICS-

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： The Gazette is the official journal of the Egyptian Pediatric Association. The main purpose of the Gazette is to provide a place for the publication of high-quality papers documenting recent advances and new developments in both pediatrics and pediatric surgery in clinical and experimental settings. An equally important purpose of the Gazette is to publish local and regional issues related to children and child care. The Gazette welcomes original papers, review articles, case reports and short communications as well as short technical reports. Papers submitted to the Gazette are peer-reviewed by a large review board. The Gazette also offers CME quizzes, credits for which can be claimed from either the EPA website or the EPA headquarters. Fields of interest: all aspects of pediatrics, pediatric surgery, child health and child care. The Gazette complies with the Uniform Requirements for Manuscripts submitted to biomedical journals as recommended by the International Committee of Medical Journal Editors (ICMJE).