Long-term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-11 DOI:10.1111/gtc.13112

Haruna Yokoi, Jingshu Wang, Yoriko Ikuyo, Mitsuyoshi Yamada, Yosuke Shikama, Masae Furukawa, Kenji Matsushita

引用次数: 0

Abstract

The systemic effects of the artificial sweetener sorbitol on older adult individuals have not been elucidated. We assessed the effects of sorbitol consumption on cognitive and gingival health in a mouse model. Aged mice were fed 5% sorbitol for 3 months before their behavior was assessed, and brain and gingival tissues were collected. Long-term sorbitol consumption inhibited gingival tissue aging in aged mice. However, it caused cognitive decline and decreased brain-derived neurotrophic factor (BDNF) in the hippocampus. Sorbitol consumption did not affect homeostatic function; however, it may exert effects within the brain, particularly in the hippocampus.

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长期食用山梨醇会影响老年小鼠的海马并改变其认知功能。

人工甜味剂山梨醇对老年人的全身影响尚未阐明。我们在小鼠模型中评估了食用山梨醇对认知能力和牙龈健康的影响。在对老年小鼠的行为进行评估之前，先喂食 5%的山梨醇 3 个月，并采集脑组织和牙龈组织。长期食用山梨醇可抑制老年小鼠牙龈组织的老化。然而，山梨醇会导致认知能力下降，并降低海马中的脑源性神经营养因子（BDNF）。摄入山梨醇不会影响体内平衡功能；但它可能会对大脑，尤其是海马产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.