Short tandem repeats — how microsatellites became the currency of forensic genetics

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2024-03-11 DOI:10.1038/s41576-024-00721-1

Bruce Budowle, Antti Sajantila

引用次数: 0

Abstract

Short tandem repeats (STRs), also known as microsatellites, are the primary markers of forensic genetics for developing investigative leads in criminal cases and humanitarian efforts. Their variation in length and sequence provides genetic information even in samples of low quantity and quality, enabling high resolution for identification and attribution purposes, and culminating in the development of national DNA databases. Bruce Budowle and Antti Sajantila reflect on how short tandem repeats (STRs) became the primary markers of forensic genetics, including for developing investigative leads in criminal cases and humanitarian efforts.

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短串联重复序列--微卫星如何成为法医遗传学的通行证

短串联重复序列（STR），又称微卫星，是法医遗传学的主要标记，用于开发刑事案件和人道主义工作的调查线索。即使样本数量少、质量差，它们在长度和序列上的变化也能提供遗传信息，从而实现高分辨率的身份识别和归属目的，并最终促成了国家 DNA 数据库的开发。布鲁斯-布道尔（Bruce Budowle）和安蒂-萨扬蒂拉（Antti Sajantila）探讨了短串联重复序列 (STR) 如何成为法医遗传学的主要标记，包括用于开发刑事案件和人道主义工作的调查线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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