Cis-Platinum and CXCR4 siRNA Carried with Cellulose Nanopaper Restrain the Biological Effect of Breast Carcinoma Cells

Abstract

Cellulose nanopaper (CNP) is a kind of flat foldable film material composed of cellulose nanofibers. Cellulose nanopaper is based on nanocellulose (NC) as the basic unit, with excellent mechanical properties, thermal properties, optical properties and other characteristics, is a high-performance new material. This study discusses the mechanism of cis-platinum and CXCR4 siRNA carried with CNP in restraining the biological effect of breast carcinoma cells. CXCR4 siRNA carried with CNP was established and identified. The MCF-7 cells were divided into control set, si-CXCR4 set, cis-platinum set and united set randomly. The proliferative and apoptotic activity, CXCR4 presentation, presentation of EMT, and invasive ability were detected. mRNA and protein expression of CXCR4 was restrained by knockdown of CXCR4 notably. The proliferation was restrained and apoptosis was prompted. Expression of E-cadherin was increased and Zeb1 presentation was reduced. The invasive ability was restrained. The action was more notable in united set. Breast carcinoma cell proliferation was restrained and the apoptosis was prompted by cis-platinum and CXCR4 siRNA carried with CNP. The occurrence of EMT and invasion were therefore restrained. The sensibility of breast carcinoma on drugs was elevated.