Intravascular papillary endothelial hyperplasia of the upper lip

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
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Abstract

Intravascular papillary endothelial hyperplasia (IPEH) is a benign lesion characterized by reactive proliferation of endothelial cells with papillary formations related to thrombosed blood vessels. IPEH in the oral region is relatively rare, and its clinical picture is not specific. Herein, we report the case of a patient with IPEH of the upper lip who had a favorable outcome. A man in his 40 s presented to our department with a nodule beneath the right upper labial mucosa. Magnetic resonance imaging showed a relatively well-defined mass. Based on the diagnosis of a benign tumor, a total excision with healthy margins was performed. Histopathological and immunohistochemical findings revealed a pure form of IPEH with a Ki-67 labeling index of 20%. No recurrence was observed 1 year postoperatively. Although IPEH in the oral region is relatively rare, and its clinical presentation is nonspecific, based on the clinical diagnosis of benign tumors, adequate excision with clear margins can reduce the risk of recurrence. As Ki-67 can be used to predict the biological behavior and risk of IPEH recurrence, careful follow-up considering the risk of recurrence suggested by the Ki-67 labeling index is needed. Thorough knowledge of IPEH is important for clinicians and pathologists to arrive at a correct diagnosis, which leads to appropriate treatment.

上唇血管内乳头状内皮增生症
血管内乳头状内皮增生(IPEH)是一种良性病变,其特点是内皮细胞反应性增生,并伴有与血栓形成的血管有关的乳头状形态。口腔区域的 IPEH 比较罕见,其临床表现也没有特异性。在此,我们报告了一例上唇 IPEH 患者,该患者的治疗效果良好。一名 40 多岁的男子因右上唇粘膜下的结节来我科就诊。磁共振成像显示肿块轮廓相对清晰。在诊断为良性肿瘤的基础上,进行了边缘健康的全切除术。组织病理学和免疫组化结果显示,这是一种纯粹的 IPEH,Ki-67 标记指数为 20%。术后一年未见复发。虽然口腔部位的 IPEH 比较罕见,而且其临床表现也没有特异性,但根据良性肿瘤的临床诊断,适当切除并保留清晰的边缘可以降低复发风险。由于Ki-67可用于预测IPEH的生物学行为和复发风险,因此需要根据Ki-67标记指数提示的复发风险进行仔细随访。对 IPEH 的透彻了解对于临床医生和病理学家做出正确诊断并进行适当治疗非常重要。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
129
审稿时长
83 days
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