Effect of Intravenous Vitamin C on Serum Level and Urinary Excretion of Methadone in Patients with Methadone Poisoning: A Randomized Single-Blind Clinical Trial

Q4 Medicine

International Journal of High Risk Behaviors and Addiction Pub Date : 2024-03-06 DOI:10.5812/ijhrba-140167

B. Ghiasi, Z. Khalighi, Maryam Sadat Hashemi, Amin Mirzaei, Naser Abbasi, Aliashraf Mozafari

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Abstract

Background: Methadone poisoning intentionally or accidentally leads to a high rate of treatment burden and cost and deaths. The evaluation of the factors affecting the severity of poisoning can reduce recovery time, costs, and potential risks. Objectives: This study aimed to investigate the effect of intravenous vitamin C (ascorbic acid) administration on serum level and urinary excretion of methadone. Methods: In this single-blind study, 54 patients who were diagnosed with methadone poisoning were divided into three groups. The two intervention groups received different doses of vitamin C, including 12 and 24 g, and the control group received normal saline. The serum methadone level and urine pH were measured at the time of arrival and 24 hours after admission. The data were analyzed using repeated measure analysis of variance (ANOVA) in STATA version 12. Results: In this study, 18 patients were placed in each group. The three groups were not significantly different in basic variables, such as age, gender, and methadone dosage. Between and within-group comparison showed a significant decrease in the serum methadone levels over time after adjusting age, gender and methadone dosage (P < 0.05). Post-hoc analyses revealed a significant difference in methadone reduction between 12 g of vitamin C and control groups (P = 0.04), and there was no significant difference between the control and 24 g of vitamin C groups (P > 0.05). However, between and within-group comparisons showed no significant difference between the three groups in terms of urine pH (P > 0.05). In addition, interaction was observed between intervention and time on serum methadone levels (P < 0.001) and urine pH (P = 0.04) variables. Conclusions: Consuming 12 g of vitamin C further reduced the serum methadone level in patients with methadone poisoning. There was no effect on methadone urinary excretion in patients.

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静脉注射维生素 C 对美沙酮中毒患者血清中美沙酮水平和尿液中美沙酮排泄量的影响：随机单盲临床试验

背景：美沙酮蓄意或意外中毒会导致很高的治疗负担、费用和死亡率。评估影响中毒严重程度的因素可以缩短康复时间、降低成本和潜在风险。研究目的本研究旨在探讨静脉注射维生素 C（抗坏血酸）对美沙酮血清水平和尿液排泄的影响。方法：采用单盲法：在这项单盲研究中，54 名被诊断为美沙酮中毒的患者被分为三组。干预组服用不同剂量的维生素 C，包括 12 克和 24 克，对照组服用生理盐水。分别在患者入院时和入院后 24 小时测量其血清美沙酮水平和尿液 pH 值。数据采用 STATA 12 版本的重复测量方差分析（ANOVA）进行分析。结果在这项研究中，每组有 18 名患者。三组患者在年龄、性别和美沙酮剂量等基本变量上没有明显差异。组间和组内比较显示，在调整年龄、性别和美沙酮剂量后，血清美沙酮水平随时间推移明显下降（P < 0.05）。事后分析表明，12 克维生素 C 组与对照组的美沙酮减少量存在显著差异（P = 0.04），对照组与 24 克维生素 C 组之间没有显著差异（P > 0.05）。然而，组间和组内比较显示，三组的尿液 pH 值无明显差异（P > 0.05）。此外，还观察到干预和时间对血清美沙酮水平（P < 0.001）和尿液 pH 值（P = 0.04）变量的交互作用。结论服用 12 克维生素 C 可进一步降低美沙酮中毒患者的血清美沙酮水平。对美沙酮患者的尿液排泄没有影响。

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来源期刊

International Journal of High Risk Behaviors and Addiction Psychology-Clinical Psychology

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of High Risk Behaviors and Addiction is a clinical journal which is informative to all fields related to the high risk behaviors, addiction, including smoking, alcohol consumption and substance abuse, unsafe sexual behavior, obesity and unhealthy eating habits, physical inactivity, and violence, suicidal behavior, and self-injurious behaviors. International Journal of High Risk Behaviors and Addiction is an authentic clinical journal which its content is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates, and consensus statements of the clinical relevance of Risky behaviors and addiction. In addition, consensus evidential reports not only highlight the new observations, original research and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in this journal.