Senolytic Drugs: Implications for Clinical Practice

Abstract

Studying the mechanisms of aging is one of the most important goals of modern science. A significant amount of data on the processes associated with a decrease in the functional ability to regenerate, cell proliferation and resistance to adverse factors with age has been accumulated due to fundamental research. The aim of the review was to study the mechanism of drugs with the senolytic activity, to determine the main targets of their effect at the cellular level, and also to evaluate the prospects for their clinical use. The relevance of this topic is confirmed by the increasing number of clinical trials of senolytics, many of which have ambiguous results and require further analysis and elimination of revealed difficulties and shortcomings. We reviewed the literature on Pubmed and Scopus platforms over the past 10 years in order to find information about the mechanisms of senotherapy and the possibility of using senolytics in clinical medicine. The focus was on those senolytic drugs that were used in clinical studies.