The trends and incidence of alcohol-associated hepatitis hospitalizations from 2016–2020 and the impact of the COVID-19 pandemic

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol Pub Date : 2024-03-08 DOI:10.1016/j.alcohol.2024.03.003

Megan B. Ghai , Pooja Rangan , Naim Alkhouri , Jessica Mellinger , Karn Wijarnpreecha

{"title":"The trends and incidence of alcohol-associated hepatitis hospitalizations from 2016–2020 and the impact of the COVID-19 pandemic","authors":"Megan B. Ghai , Pooja Rangan , Naim Alkhouri , Jessica Mellinger , Karn Wijarnpreecha","doi":"10.1016/j.alcohol.2024.03.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>The impact of the COVID-19 pandemic on hospitalizations for alcohol-associated hepatitis (AH) is poorly understood. Here we explore AH trends from 2016 to 2020 and evaluate demographic disparities including sex and race.</div></div><div><h3>Methods</h3><div>A retrospective analysis of the 2016–2020 Healthcare Cost and Utilization Project National Inpatient Sample was performed to assess temporal trends in hospitalizations for AH. The 2020 dataset was evaluated to compare AH hospitalizations between those with and without an additional diagnosis of COVID-19.</div></div><div><h3>Results</h3><div>Included were 607 140 weighted inpatient AH discharges per 145,055,152 all-cause discharges from 2016 to 2020. AH hospitalizations increased at a rate of 23.4 hospitalizations per 100 000 all-cause discharges per year between 2016 and 2019 and increased to 113 hospitalizations per 100 000 all-cause discharges in 2020. Mortality was higher in females despite lower rates of hospitalization than males. The adjusted odds of hospitalization for AH in 2020 were higher than in 2016–2019 (aOR = 1.28, <em>p</em> < 0.001). The Hispanic population had greater odds of hospitalization with AH and COVID-19 compared to other races (aOR = 2.71, <em>p</em> < 0.001).</div></div><div><h3>Discussion</h3><div>Increased efforts toward primary prevention of excessive alcohol use and greater social support for those with alcohol use disorder are needed. More research is required to elucidate the racial disparities among the Hispanic population with AH and COVID-19.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 177-184"},"PeriodicalIF":2.5000,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0741832924000399","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

The impact of the COVID-19 pandemic on hospitalizations for alcohol-associated hepatitis (AH) is poorly understood. Here we explore AH trends from 2016 to 2020 and evaluate demographic disparities including sex and race.

Methods

A retrospective analysis of the 2016–2020 Healthcare Cost and Utilization Project National Inpatient Sample was performed to assess temporal trends in hospitalizations for AH. The 2020 dataset was evaluated to compare AH hospitalizations between those with and without an additional diagnosis of COVID-19.

Results

Included were 607 140 weighted inpatient AH discharges per 145,055,152 all-cause discharges from 2016 to 2020. AH hospitalizations increased at a rate of 23.4 hospitalizations per 100 000 all-cause discharges per year between 2016 and 2019 and increased to 113 hospitalizations per 100 000 all-cause discharges in 2020. Mortality was higher in females despite lower rates of hospitalization than males. The adjusted odds of hospitalization for AH in 2020 were higher than in 2016–2019 (aOR = 1.28, p < 0.001). The Hispanic population had greater odds of hospitalization with AH and COVID-19 compared to other races (aOR = 2.71, p < 0.001).

Discussion

Increased efforts toward primary prevention of excessive alcohol use and greater social support for those with alcohol use disorder are needed. More research is required to elucidate the racial disparities among the Hispanic population with AH and COVID-19.

查看原文本刊更多论文

2016-2020 年酒精相关肝炎住院治疗的趋势和发病率，以及 covid-19 大流行的影响。

导言：人们对 COVID-19 大流行对酒精相关性肝炎（AH）住院治疗的影响知之甚少。在此，我们探讨了 2016-2020 年酒精相关性肝炎的发展趋势，并评估了包括性别和种族在内的人口统计学差异：方法：我们对 2016-2020 年医疗成本与利用项目全国住院患者样本进行了回顾性分析，以评估 AH 住院治疗的时间趋势。对 2020 年的数据集进行了评估，以比较有 COVID-19 附加诊断和没有 COVID-19 附加诊断的 AH 住院情况：结果：2016-2020年间，每145,055,152例全因出院病例中有607,140例加权AH住院病例。2016-2019 年间，AH 住院率以每年每 10 万例全因出院患者 23.4 例的速度增长，到 2020 年将增至每 10 万例全因出院患者 113 例。尽管住院率低于男性，但女性的死亡率更高。2020 年调整后的 AH 住院几率高于 2016-2019 年（aOR= 1.28，p <0.001）。与其他种族相比，西班牙裔人群因 AH 和 COVID-19 住院的几率更高（aOR= 2.71，p 讨论）：需要加大力度对过度饮酒进行初级预防，并为酗酒者提供更多的社会支持。需要开展更多研究，以阐明西语裔人群中酗酒和 COVID-19 的种族差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.