Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids.

Eduardo Leyva-Díaz, Emily S Wilson, Guillermina López-Bendito
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Abstract

Dissecting the role of the thalamus in neuropsychiatric disorders requires new models to analyze complex genetic interactions. In this issue of Cell Stem Cell, Shin et al. use patient-derived thalamocortical organoids to investigate 22q11.2 microdeletion impact on thalamic development, revealing significant transcriptional dysregulation linked to psychiatric disorders.

发育有了答案:通过丘脑皮层有机体揭开精神疾病的神秘面纱
剖析丘脑在神经精神疾病中的作用需要新的模型来分析复杂的基因相互作用。在本期《细胞干细胞》(Cell Stem Cell)杂志上,Shin等人利用源自患者的丘脑皮质器官组织研究22q11.2微缺失对丘脑发育的影响,揭示了与精神疾病有关的显著转录失调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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