RNA therapeutics for regenerative medicine.

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI:10.1016/bs.pmbts.2023.12.002

Yen Vy Nguyen Thi, Anh Dao Ngo, Dinh-Toi Chu, Sheng-Che Lin, Chia-Ching Wu

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引用次数: 0

Abstract

It is estimated that millions of people around the world experience various types of tissue injuries every year. Regenerative medicine was born and developed for understanding and application with the aim of replacing affected organs or some cells. The research, manufacture, production, and distribution of RNA in cells have acted as a basic foundation for the development and testing of therapies and treatments that are widely applied in different fields of medicine. Vaccines against COVID-19 are considered one of the brilliant and outstanding successes of RNA therapeutics research. With the characteristics of bio-derived RNA therapeutics, the mechanism of rapid implementation, safe production, and flexibility to create proteins depending on actual requirements. Based on the advantages above in this review, we discuss RNA therapeutics for regenerative medicine, and the types of RNA therapies currently being used for regenerative medicine. The relationship between disease and regenerative medicine is currently being studied or tested in RNA therapeutics. We have also covered the mechanisms of action of RNA therapy for regenerative medicine and some of the limitations in our current understanding of the effects of RNA therapy in this area. Additionally, we have also covered developing RNA therapeutics for regenerative medicine, focusing on RNA therapeutics for regenerative medicine. As a final point, we discuss potential applications for therapeutics for regenerative medicine in the future, as well as their mechanisms.

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用于再生医学的 RNA 疗法。

据估计，全世界每年有数百万人遭受各种组织损伤。再生医学应运而生，并在理解和应用方面得到发展，其目的是替换受影响的器官或某些细胞。RNA在细胞中的研究、制造、生产和分布为开发和测试广泛应用于不同医学领域的疗法和治疗方法奠定了基础。针对 COVID-19 的疫苗被认为是 RNA 疗法研究的辉煌成就之一。RNA 疗法具有生物衍生的特点，其机制实施迅速、生产安全、可根据实际需求灵活创建蛋白质。基于上述优势，我们在本综述中讨论了再生医学中的 RNA 疗法，以及目前用于再生医学的 RNA 疗法类型。目前，RNA 疗法正在研究或测试疾病与再生医学之间的关系。我们还介绍了用于再生医学的 RNA 疗法的作用机制，以及我们目前对该领域中 RNA 疗法效果的理解存在的一些局限性。此外，我们还介绍了用于再生医学的 RNA 疗法的开发，重点关注用于再生医学的 RNA 疗法。最后，我们讨论了再生医学疗法在未来的潜在应用及其机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in molecular biology and translational science 生物-生化与分子生物学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.