Role of circular RNA as competing endogenous RNA in ovarian cancer (Review).

IF 5.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

International journal of molecular medicine Pub Date : 2024-05-01 Epub Date: 2024-03-08 DOI:10.3892/ijmm.2024.5365

Wanlu Ye, Nan Xiang, Qing Wang, Yanming Lu

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引用次数: 0

Abstract

Circular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various diseases and are currently recognized as the most prominent mechanism of action of circRNAs. circRNAs can modulate the proliferation, migration, invasion and apoptosis of tumor cells through the ceRNA mechanism. With further research, circRNAs may serve as novel markers and therapeutic targets for ovarian cancer (OC). In the present review, the research progress of circRNAs as ceRNAs in OC was summarized, focusing on the effects of the circRNA/miRNA/mRNA axis on the biological functions of OC cells through mediating pivotal signaling pathways. The role of circRNAs in the diagnosis, prognostic assessment and treatment of OC was also discussed in the present review.

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环状 RNA 作为竞争性内源性 RNA 在卵巢癌中的作用（综述）。

环状 RNA（circRNA）是一种非编码 RNA，在生物过程中发挥着调控作用。circRNA 的特殊环状结构使其在病变组织和细胞（尤其是肿瘤）中具有高度稳定性和特异性。竞争性内源性 RNA（ceRNA）在特定的结合位点上竞争性地与 microRNA（miRNA）结合，从而调控基因表达。ceRNA 在各种疾病中发挥着重要作用，是目前公认的 circRNA 最主要的作用机制。随着研究的深入，circRNAs可能成为卵巢癌（OC）的新型标志物和治疗靶点。本综述总结了circRNAs作为ceRNAs在OC中的研究进展，重点探讨了circRNA/miRNA/mRNA轴通过介导关键信号通路对OC细胞生物学功能的影响。本综述还讨论了 circRNAs 在 OC 诊断、预后评估和治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of molecular medicine 医学-医学：研究与实验

CiteScore

12.30

自引率

0.00%

发文量

124

审稿时长

3 months

期刊介绍： The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.