{"title":"IL-15 in T-Cell Responses and Immunopathogenesis.","authors":"Hoyoung Lee, Su-Hyung Park, Eui-Cheol Shin","doi":"10.4110/in.2024.24.e11","DOIUrl":null,"url":null,"abstract":"<p><p>IL-15 belongs to the common gamma chain cytokine family and has pleiotropic immunological functions. IL-15 is a homeostatic cytokine essential for the development and maintenance of NK cells and memory CD8<sup>+</sup> T cells. In addition, IL-15 plays a critical role in the activation, effector functions, tissue residency, and senescence of CD8<sup>+</sup> T cells. IL-15 also activates virtual memory T cells, mucosal-associated invariant T cells and γδ T cells. Recently, IL-15 has been highlighted as a major trigger of TCR-independent activation of T cells. This mechanism is involved in T cell-mediated immunopathogenesis in diverse diseases, including viral infections and chronic inflammatory diseases. Deeper understanding of IL-15-mediated T-cell responses and their underlying mechanisms could optimize therapeutic strategies to ameliorate host injury by T cell-mediated immunopathogenesis. This review highlights recent advancements in comprehending the role of IL-15 in relation to T cell responses and immunopathogenesis under various host conditions.</p>","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917573/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immune Network","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4110/in.2024.24.e11","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
IL-15 belongs to the common gamma chain cytokine family and has pleiotropic immunological functions. IL-15 is a homeostatic cytokine essential for the development and maintenance of NK cells and memory CD8+ T cells. In addition, IL-15 plays a critical role in the activation, effector functions, tissue residency, and senescence of CD8+ T cells. IL-15 also activates virtual memory T cells, mucosal-associated invariant T cells and γδ T cells. Recently, IL-15 has been highlighted as a major trigger of TCR-independent activation of T cells. This mechanism is involved in T cell-mediated immunopathogenesis in diverse diseases, including viral infections and chronic inflammatory diseases. Deeper understanding of IL-15-mediated T-cell responses and their underlying mechanisms could optimize therapeutic strategies to ameliorate host injury by T cell-mediated immunopathogenesis. This review highlights recent advancements in comprehending the role of IL-15 in relation to T cell responses and immunopathogenesis under various host conditions.
IL-15 属于常见的γ链细胞因子家族，具有多种免疫功能。IL-15 是一种平衡细胞因子，对 NK 细胞和记忆性 CD8+ T 细胞的发育和维持至关重要。此外，IL-15 还在 CD8+ T 细胞的活化、效应功能、组织驻留和衰老过程中发挥关键作用。IL-15 还能激活虚拟记忆 T 细胞、粘膜相关不变 T 细胞和 γδ T 细胞。最近，IL-15 被强调为 TCR 依赖性活化 T 细胞的主要触发因子。这一机制参与了包括病毒感染和慢性炎症性疾病在内的多种疾病的 T 细胞介导的免疫发病机制。深入了解 IL-15 介导的 T 细胞反应及其内在机制可优化治疗策略，改善 T 细胞介导的免疫发病机制对宿主造成的伤害。本综述重点介绍了最近在理解 IL-15 在各种宿主条件下与 T 细胞反应和免疫发病机制有关的作用方面取得的进展。
期刊介绍：
Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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