Rabab Fawzy Hindawy, Samia M Manawy, Ola Elsayed Nafea, Abeer A Abdelhameed, Fatma Fawzi Hendawi
{"title":"<i>Moringa oleifera</i> leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats.","authors":"Rabab Fawzy Hindawy, Samia M Manawy, Ola Elsayed Nafea, Abeer A Abdelhameed, Fatma Fawzi Hendawi","doi":"10.1093/toxres/tfae028","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. <i>Moringa oleifera</i> (<i>M. oleifera</i>), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of <i>M. oleifera</i> extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats.</p><p><strong>Materials and methods: </strong>Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, <i>M. oleifera</i> extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed.</p><p><strong>Results: </strong>Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures.</p><p><strong>Conclusions: </strong>We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.</p>","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 2","pages":"tfae028"},"PeriodicalIF":2.2000,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917235/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/toxres/tfae028","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. Moringa oleifera (M. oleifera), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of M. oleifera extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats.
Materials and methods: Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, M. oleifera extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed.
Results: Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures.
Conclusions: We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
