MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery

IF 4.7 2区医学 Q1 RESPIRATORY SYSTEM

Respiratory Research Pub Date : 2024-03-07 DOI:10.1186/s12931-024-02747-9

Judith van Paassen, Pieter S. Hiemstra, Abraham C. van der Linden, Evert de Jonge, Jaap Jan Zwaginga, Robert J.M. Klautz, M. Sesmu Arbous

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Abstract

Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pre- and post-surgery non-fiberscopic miniBAL fluids were analysed for MUC5AC, MUC5B, IL-8, human neutrophil elastase, and neutrophils. All measured biomarkers increased after surgery. Perioperative MUC5AC-change showed a significant negative association with postoperative P/F ratio (p = 0.018), and a positive association with ICU stay (p = 0.027). In conclusion, development of lung injury after cardiac surgery and prolonged ICU stay are associated with an early increase of MUC5AC as detected in mini-BAL.

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肺灌洗液中的 MUC5AC 浓度与心脏手术后急性肺损伤有关

心脏手术可能会并发急性肺损伤和成人呼吸窘迫综合征。据报道，急性肺损伤时肺部粘蛋白 MUC5AC 和 MUC5B 的表达和释放增加。我们的研究旨在[1]调查围手术期微型支气管肺泡灌洗液（minBAL）中 MUC5AC、MUC5B 及其他生物标志物的变化，并[2]将其与心脏手术后的临床结果联系起来。在这项前瞻性队列研究中，对 49 名成人心脏手术患者进行了手术前和手术后非纤维化迷你肺泡灌洗液的 MUC5AC、MUC5B、IL-8、人中性粒细胞弹性蛋白酶和中性粒细胞分析。所有测定的生物标志物在手术后都有所增加。围手术期 MUC5AC 的变化与术后 P/F 比值呈显著负相关（p = 0.018），与重症监护病房的住院时间呈正相关（p = 0.027）。总之，心脏手术后肺损伤的发生和ICU住院时间的延长与迷你BAL检测到的MUC5AC的早期增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Research 医学-呼吸系统

自引率

1.70%

发文量

314

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.