Significance of plasma relaxin-2 levels in patients with primary hypertension and type 2 diabetes mellitus.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-01 Epub Date: 2024-03-07 DOI:10.1007/s10354-024-01035-x

Olena Pankova, Oleksii Korzh

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Abstract

Background: This study aimed to evaluate plasma relaxin‑2 (RLN-2) levels in patients with arterial hypertension (AH) and their relationships with clinical and laboratory parameters.

Methods: The study involved 106 hypertensive patients, including 55 with type 2 diabetes mellitus (T2DM), and 30 control subjects. Plasma RLN-2 levels were measured using an enzyme-linked immunosorbent assay kit.

Results: RLN-2 levels were reduced in patients with AH compared to healthy volunteers (p < 0.001), and hypertensive patients with T2DM had lower RLN-2 levels than those without impaired glucose metabolism (p < 0.001). RLN‑2 was negatively correlated with systolic blood pressure (SBP) (p < 0.001) and anthropometric parameters such as body mass index (BMI; p = 0.027), neck (p = 0.045) and waist (p = 0.003) circumferences, and waist-to-hip ratio (p = 0.011). RLN‑2 also had inverse associations with uric acid levels (p = 0.019) and lipid profile parameters, particularly triglycerides (p < 0.001) and non-HDL-C/HDL‑C (p < 0.001), and a positive relationship with HDL‑C (p < 0.001). RLN‑2 was negatively associated with glucose (p < 0.001), insulin (p = 0.043), HbA1c (p < 0.001), and HOMA-IR index (p < 0.001). Univariate binary logistic regression identified RLN‑2 as a significant predictor of impaired glucose metabolism (p < 0.001).

Conclusions: Decreased RLN-2 levels in patients with AH and T2DM and established relationships of RLN‑2 with SBP and parameters of glucose metabolism and lipid profile suggest a diagnostic role of RLN‑2 as a biomarker for AH with T2DM.

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原发性高血压和 2 型糖尿病患者血浆松弛素-2 水平的意义。

背景：本研究旨在评估动脉高血压（AH）患者血浆松弛素-2（RLN-2）水平及其与临床和实验室指标的关系：本研究旨在评估动脉高血压（AH）患者的血浆松弛素-2（RLN-2）水平及其与临床和实验室指标的关系：研究涉及 106 名高血压患者（包括 55 名 2 型糖尿病（T2DM）患者）和 30 名对照组受试者。使用酶联免疫吸附测定试剂盒测定血浆 RLN-2 水平：结果：与健康志愿者相比，AH 患者的 RLN-2 水平降低了（p 结论：AH 患者的 RLN-2 水平降低了：AH和T2DM患者的RLN-2水平降低，以及RLN-2与SBP、糖代谢参数和血脂谱的既定关系表明，RLN-2可作为AH和T2DM的生物标志物用于诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.