[Patient-reported outcomes in chronic diseases under treatment with cannabis medicines : Analysis of the results of the Copeia survey].

IF 1.1 4区 医学 Q3 ANESTHESIOLOGY
Schmerz Pub Date : 2024-08-01 Epub Date: 2024-03-07 DOI:10.1007/s00482-024-00802-4
Knud Gastmeier, André Ihlenfeld, Anne Gastmeier, Garvin Hirt, Assaf Landschaft, Stefan Wirz
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引用次数: 0

Abstract

Background: The survey of Copeia captured early 2022 patient-reported outcomes (PRO) in Germany under cannabis medicinal product (CAM) therapy, with particular attention to symptoms, symptom changes, indications, side effects, dosages, and cost bearers.

Goal: This study investigated the question of whether associations emerge from the results that could play a role in the indication and treatment monitoring of CAM in chronically ill patients.

Materials and methods: A standardized questionnaire was administered online nationwide in dialogue form over a 15-week period to collect itemized symptoms and PRO. Recruitment was supported by pharmacies, prescribing physicians, and patient associations. Inclusion criteria included physician-prescribed CAM therapy.

Results and discussion: Of 1582 participants, 1030 data sets (65%) could be completely analyzed. There was a heterogeneous patient population, whose common feature was disease chronicity. The frequency distribution of symptoms showed a homogeneous pattern for the respective indications, in which the most frequent six (pain 71%, sleep disturbance 64%, stress/tension 52%, inner restlessness 52%, depressive mood 44% and muscle tension 43%) seem to have a special significance. According to subjective assessment, quality of life improved significantly in 84% of all participating patients.

Conclusion: A symptom matrix (SMX) composed of different symptoms seems to play a special role in CAM therapy to improve the quality of life of chronically ill patients, regardless of the underlying disease. The SMX could contribute to the identification of an indication and to targeted treatment monitoring.

Abstract Image

[使用大麻药物治疗慢性疾病的患者报告结果:Copeia 调查结果分析]。
背景:Copeia调查收集了德国2022年早期接受大麻药用产品(CAM)治疗的患者报告结果(PRO),特别关注症状、症状变化、适应症、副作用、剂量和费用承担者。目标:本研究探讨了从调查结果中是否可以发现一些关联,从而在慢性病患者的CAM适应症和治疗监测中发挥作用:在为期 15 周的时间内,在全国范围内以对话形式在线发放了一份标准化问卷,以收集逐项症状和 PRO。招募工作得到了药房、处方医生和患者协会的支持。纳入标准包括医生处方的 CAM 疗法:在 1582 名参与者中,有 1030 组数据(65%)可进行完整分析。患者群体具有异质性,其共同特征是疾病的慢性化。症状的频率分布显示出相应适应症的同质性模式,其中最常见的六种症状(疼痛 71%、睡眠障碍 64%、压力/紧张 52%、内心不安 52%、抑郁情绪 44%和肌肉紧张 43%)似乎具有特殊意义。根据主观评估,84%的参与患者的生活质量得到明显改善:由不同症状组成的症状矩阵(SMX)似乎在 CAM疗法中发挥着特殊作用,无论潜在疾病如何,它都能改善慢性病患者的生活质量。症状矩阵有助于确定适应症和有针对性的治疗监测。
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来源期刊
Schmerz
Schmerz 医学-临床神经学
CiteScore
2.00
自引率
20.00%
发文量
64
审稿时长
6-12 weeks
期刊介绍: Der Schmerz is an internationally recognized journal and addresses all scientists, practitioners and psychologists, dealing with the treatment of pain patients or working in pain research. The aim of the journal is to enhance the treatment of pain patients in the long run. Review articles provide an overview on selected topics and offer the reader a summary of current findings from all fields of pain research, pain management and pain symptom management. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.
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