Design, synthesis, and insecticidal activities of the novel sulfur-containing meta-amide compounds as potential pesticides

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Research Pub Date : 2024-03-05 DOI:10.1177/17475198241234629

Yan Zhang, Jingwen Wu, Shuaihui Dang, Sha Zhou, Jifen Wang, Ruixue Wang

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Abstract

The potential risks associated with the high halogen content of typical meta-amide ( m-diamide) insecticidals aroused concerns among researchers. Hoping to make discoveries by introducing sulfur elements with good environmental compatibility, a series of novel sulfur-containing m-amide derivatives C were synthesized through exploration under mild conditions according to the literature. And the structures were confirmed by melting points, 1H NMR, 13C NMR, 19F NMR, and HRMS. It was found that some target compounds C exhibited moderate to high insecticidal activities against Aphis craccivora (38.89%–75.00%) and Plutella xylostella (93.33%−100.00%) at 500 mg.L−1. Especially, the sulfone-containing compound C-3 revealed superior lethality rates against P. xylostella (100%, 12.5 mg.L−1) and A. craccivora (75.00%, 500 mg.L−1), suggesting its potential as a leading compound for further investigation.

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作为潜在杀虫剂的新型含硫偏酰胺化合物的设计、合成和杀虫活性

典型的间二酰胺类杀虫剂中卤素含量较高，其潜在风险引起了研究人员的关注。研究人员希望通过引入与环境相容性良好的硫元素来有所发现，并根据文献，在温和条件下探索合成了一系列新型含硫间二胺衍生物 C。并通过熔点、1H NMR、13C NMR、19F NMR 和 HRMS 对其结构进行了确认。研究发现，一些目标化合物 C 在 500 mg.L-1 的浓度下对蚜虫（38.89%-75.00%）和褐飞虱（93.33%-100.00%）具有中等到较高的杀虫活性。特别是含砜化合物 C-3 对 P. xylostella（100%，12.5 mg.L-1）和 A. craccivora（75.00%，500 mg.L-1）的致死率较高，表明其有可能成为进一步研究的主要化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Research CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

1.0 months

期刊介绍： The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry. Established in 1977 as a joint venture by the British, French and German chemical societies it maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted. Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes.