Interferon-beta-1a induced retinopathy in a 14-year-old female patient with multiple sclerosis

C. Tsimakidi, M. Gontika, D. Gkougka, K Rizonaki, S. Fanouraki, C. Kotsalis
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Abstract

Interferon (INF) b-1a is a widely used medication, administered as first-line treatment in adult and pediatric patients with multiple sclerosis (MS). Common adverse reactions include flu-like symptoms, skin changes, allergic reactions and depression.

Interferon-induced retinopathy commonly arises in HCV patients treated with INFa, but has rarely been associated with IFNb administration in adults.

We present a 14-year-old female, newly diagnosed with MS, that presented with interferon-induced retinopathy, five months after IFNb-1a initiation. The medication was discontinued with complete recovery.

To our knowledge, this is the first reported case of IFNb-induced retinopathy in a pediatric patient.

一名 14 岁女性多发性硬化症患者因干扰素-β-1a 引起的视网膜病变
干扰素(INF)b-1a 是一种广泛使用的药物,是成人和儿童多发性硬化症(MS)患者的一线治疗药物。常见的不良反应包括流感样症状、皮肤变化、过敏反应和抑郁。干扰素诱发的视网膜病变通常发生在接受 INFa 治疗的 HCV 患者身上,但在成人患者中却很少与 IFNb 相关。我们报告了一名 14 岁的女性患者,她刚被诊断为多发性硬化症,在开始接受 IFNb-1a 治疗五个月后出现了干扰素诱发的视网膜病变。据我们所知,这是首例报道的儿童患者因 IFNb 引起视网膜病变的病例。
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