Quercetin induces ferroptosis by inactivating mTOR/S6KP70 pathway in oral squamous cell carcinoma

IF 3.2 4区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Toxicology Mechanisms and Methods Pub Date : 2024-03-04 DOI:10.1080/15376516.2024.2325989

Ya-wen Zhu, Chun-lei Liu, Xiao-mei Li, Yu Shang

引用次数: 0

Abstract

Although recent studies increasingly suggest the potential anti-cancer effect of quercetin, the exact underlying mechanism remain poorly demonstrated in oral squamous cell carcinoma (oSCC). Therefo...

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槲皮素通过灭活口腔鳞状细胞癌中的 mTOR/S6KP70 通路诱导铁变态反应

尽管最近的研究越来越多地表明槲皮素具有潜在的抗癌作用，但其在口腔鳞状细胞癌（oSCC）中的确切机制仍未得到充分证实。因此...

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来源期刊

Toxicology Mechanisms and Methods 医学-毒理学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.