Mechanism of electroconvulsive therapy in schizophrenia: a bioinformatics analysis study of RNA-seq data.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2024-04-01 Epub Date: 2024-03-01 DOI:10.1097/YPG.0000000000000362

Tingting Wang, Minglan Yu, Xiaochu Gu, Xuemei Liang, Ping Wang, Wanhong Peng, Dongmei Liu, Dechao Chen, Chaohua Huang, Youguo Tan, Kezhi Liu, Bo Xiang

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引用次数: 0

Abstract

Objective: The molecular mechanism of electroconvulsive therapy (ECT) for schizophrenia remains unclear. The aim of this study was to uncover the underlying biological mechanisms of ECT in the treatment of schizophrenia using a transcriptional dataset.

Methods: The peripheral blood mRNA sequencing data of eight patients (before and after ECT) and eight healthy controls were analyzed by integrated co-expression network analysis and the differentially expressed genes were analyzed by cluster analysis. Gene set overlap analysis was performed using the hypergeometric distribution of phypfunction in R. Associations of these gene sets with psychiatric disorders were explored. Tissue-specific enrichment analysis, gene ontology enrichment analysis, and protein-protein interaction enrichment analysis were used for gene set organization localization and pathway analysis.

Results: We found the genes of the green-yellow module were significantly associated with the effect of ECT treatment and the common gene variants of schizophrenia ( P = 0.0061; family-wise error correction). The genes of the green-yellow module are mainly enriched in brain tissue and mainly involved in the pathways of neurotrophin, mitogen-activated protein kinase and long-term potentiation.

Conclusion: Genes associated with the efficacy of ECT were predominantly enriched in neurotrophin, mitogen-activated protein kinase and long-term potentiation signaling pathways.

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精神分裂症的电休克治疗机制：RNA-seq 数据的生物信息学分析研究。

目的：电休克疗法（ECT）治疗精神分裂症的分子机制尚不清楚。本研究旨在利用转录数据集揭示电休克疗法治疗精神分裂症的潜在生物学机制：方法：采用整合共表达网络分析法分析了8名患者（ECT前后）和8名健康对照者的外周血mRNA测序数据，并采用聚类分析法分析了差异表达基因。利用 R 中的植物功能超几何分布进行了基因组重叠分析。组织特异性富集分析、基因本体富集分析和蛋白-蛋白相互作用富集分析用于基因组的组织定位和通路分析：结果：我们发现黄绿色模块的基因与 ECT 治疗效果和精神分裂症常见基因变异显著相关（P = 0.0061；家族误差校正）。黄绿色模块的基因主要富集于脑组织，主要参与神经营养素、丝裂原活化蛋白激酶和长期延时等通路：结论：与ECT疗效相关的基因主要富集在神经营养素、丝裂原活化蛋白激酶和长期延时信号通路中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.