Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia.

IF 3.5 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Ilona den Hartog, Laura B Zwep, Jacqueline J Meulman, Thomas Hankemeier, Ewoudt M W van de Garde, J G Coen van Hasselt
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引用次数: 0

Abstract

Introduction: Longitudinal biomarkers in patients with community-acquired pneumonia (CAP) may help in monitoring of disease progression and treatment response. The metabolic host response could be a potential source of such biomarkers since it closely associates with the current health status of the patient.

Objectives: In this study we performed longitudinal metabolite profiling in patients with CAP for a comprehensive range of metabolites to identify potential host response biomarkers.

Methods: Previously collected serum samples from CAP patients with confirmed Streptococcus pneumoniae infection (n = 25) were used. Samples were collected at multiple time points, up to 30 days after admission. A wide range of metabolites was measured, including amines, acylcarnitines, organic acids, and lipids. The associations between metabolites and C-reactive protein (CRP), procalcitonin, CURB disease severity score at admission, and total length of stay were evaluated.

Results: Distinct longitudinal profiles of metabolite profiles were identified, including cholesteryl esters, diacyl-phosphatidylethanolamine, diacylglycerols, lysophosphatidylcholines, sphingomyelin, and triglycerides. Positive correlations were found between CRP and phosphatidylcholine (34:1) (cor = 0.63) and negative correlations were found for CRP and nine lysophosphocholines (cor = - 0.57 to - 0.74). The CURB disease severity score was negatively associated with six metabolites, including acylcarnitines (tau = - 0.64 to - 0.58). Negative correlations were found between the length of stay and six triglycerides (TGs), especially TGs (60:3) and (58:2) (cor = - 0.63 and - 0.61).

Conclusion: The identified metabolites may provide insight into biological mechanisms underlying disease severity and may be of interest for exploration as potential treatment response monitoring biomarker.

Abstract Image

肺炎链球菌相关社区获得性肺炎的纵向代谢物分析。
简介:社区获得性肺炎(CAP)患者的纵向生物标志物有助于监测疾病进展和治疗反应。代谢宿主反应可能是此类生物标记物的潜在来源,因为它与患者当前的健康状况密切相关:在这项研究中,我们对 CAP 患者的一系列代谢物进行了纵向分析,以确定潜在的宿主反应生物标志物:方法:使用之前收集的确诊肺炎链球菌感染的 CAP 患者(n = 25)的血清样本。样本在入院后 30 天内的多个时间点采集。测定了多种代谢物,包括胺、酰基肉碱、有机酸和脂类。评估了代谢物与 C 反应蛋白 (CRP)、降钙素原、入院时 CURB 疾病严重程度评分和总住院时间之间的关系:结果:发现了不同的代谢物纵向分布,包括胆固醇酯、二酰磷脂酰乙醇胺、二酰甘油、溶血磷脂酰胆碱、鞘磷脂和甘油三酯。发现 CRP 与磷脂酰胆碱(34:1)呈正相关(cor = 0.63),CRP 与九种溶血磷脂酰胆碱呈负相关(cor = - 0.57 至 - 0.74)。CURB 疾病严重程度评分与包括酰基肉碱在内的六种代谢物呈负相关(tau = - 0.64 至 - 0.58)。住院时间与六种甘油三酯(TGs),尤其是甘油三酯(60:3)和(58:2)之间呈负相关(cor = - 0.63 和 - 0.61):所发现的代谢物可帮助人们深入了解疾病严重程度的生物机制,并有可能成为潜在的治疗反应监测生物标志物。
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来源期刊
Metabolomics
Metabolomics 医学-内分泌学与代谢
CiteScore
6.60
自引率
2.80%
发文量
84
审稿时长
2 months
期刊介绍: Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.
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