Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.

IF 1.5 Q3 PHARMACOLOGY & PHARMACY

International Journal of Pharmacy Practice Pub Date : 2024-05-07 DOI:10.1093/ijpp/riae003

Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam

引用次数: 0

Abstract

Objectives: To determine risks associated with uricosurics in COVID-19 patients.

Methods: A systematic review and meta-analysis was conducted by systematically searching electronic databases.

Key findings: The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94-1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65-0.94).

Conclusions: The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.

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尿素对 COVID-19 患者死亡率结果的影响：随机对照试验的系统回顾和荟萃分析。

目的确定COVID-19患者使用尿尿剂的相关风险：通过系统检索电子数据库，进行了系统回顾和荟萃分析：对纳入试验的汇总分析显示，使用尿素氮与死亡风险无关（汇总赔率 [OR] = 1.03，95% 置信区间 [CI]：0.94-1.12）。然而，使用抗坏血酸可能对死亡率有益（汇总赔率[OR]=0.78，95% 置信区间[CI]：0.65-0.94）：研究结果证实，尽管尿酸盐可能会导致尿酸排泄，但在COVID-19患者中使用尿酸盐是安全的，因为尿酸盐可能具有抗氧化特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Pharmacy Practice PHARMACOLOGY & PHARMACY-

CiteScore

2.90

自引率

5.60%

发文量

146

期刊介绍： The International Journal of Pharmacy Practice (IJPP) is a Medline-indexed, peer reviewed, international journal. It is one of the leading journals publishing health services research in the context of pharmacy, pharmaceutical care, medicines and medicines management. Regular sections in the journal include, editorials, literature reviews, original research, personal opinion and short communications. Topics covered include: medicines utilisation, medicine management, medicines distribution, supply and administration, pharmaceutical services, professional and patient/lay perspectives, public health (including, e.g. health promotion, needs assessment, health protection) evidence based practice, pharmacy education. Methods include both evaluative and exploratory work including, randomised controlled trials, surveys, epidemiological approaches, case studies, observational studies, and qualitative methods such as interviews and focus groups. Application of methods drawn from other disciplines e.g. psychology, health economics, morbidity are especially welcome as are developments of new methodologies.