{"title":"A Case of Weak D Serologic Phenotype.","authors":"Alice M Boshoven, Laura Verhagen","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Rh D alloimmunization is the serologic response that occurs when Rh D-negative patients are exposed to Rh D-positive blood. Rh D blood typing is recommended in pregnancy to prevent alloimmunization.</p><p><strong>Case presentation: </strong>A 27-year-old gravida 3, para 2012 (G3P2012) previously Rh D-negative female presented with discordant and weakly positive Rh D blood typing results. Confirmatory genetic testing revealed weak D phenotype that can be treated clinically as Rh D-positive.</p><p><strong>Discussion: </strong>Genetic variants of Rh D can cause varied blood typing results depending on the hospital reporting protocol utilized. If labeled as Rh D-negative, this could lead to unnecessary administration of Rh D immunoglobulin in pregnancy. Genetic variants should be suspected when patients are noted to have blood typing results that are discordant or weakly positive.</p><p><strong>Conclusions: </strong>Rh D genotyping should be considered when discordant or weakly positive Rh D blood type results are noted in order to confirm and classify genetic subtype.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"123 1","pages":"56-58"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"WMJ : official publication of the State Medical Society of Wisconsin","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Introduction: Rh D alloimmunization is the serologic response that occurs when Rh D-negative patients are exposed to Rh D-positive blood. Rh D blood typing is recommended in pregnancy to prevent alloimmunization.
Case presentation: A 27-year-old gravida 3, para 2012 (G3P2012) previously Rh D-negative female presented with discordant and weakly positive Rh D blood typing results. Confirmatory genetic testing revealed weak D phenotype that can be treated clinically as Rh D-positive.
Discussion: Genetic variants of Rh D can cause varied blood typing results depending on the hospital reporting protocol utilized. If labeled as Rh D-negative, this could lead to unnecessary administration of Rh D immunoglobulin in pregnancy. Genetic variants should be suspected when patients are noted to have blood typing results that are discordant or weakly positive.
Conclusions: Rh D genotyping should be considered when discordant or weakly positive Rh D blood type results are noted in order to confirm and classify genetic subtype.
导言：Rh D同种免疫是指Rh D阴性患者接触Rh D阳性血液后发生的血清反应。建议在妊娠期进行 Rh D 血型分型，以预防同种免疫：病例介绍：一名 27 岁、孕 3、2012 年第 3 期（G3P2012）的 Rh D 阴性女性，Rh D 血型结果不一致，呈弱阳性。经基因检测确诊为弱 D 表型，临床上可按 Rh D 阳性处理：讨论：Rh D 基因变异可导致不同的血型结果，具体取决于医院采用的报告方案。如果被标记为 Rh D 阴性，则可能导致在妊娠期不必要地使用 Rh D 免疫球蛋白。当发现患者的血型结果不一致或呈弱阳性时，应怀疑其基因变异：结论：当发现 Rh D 血型结果不一致或呈弱阳性时，应考虑进行 Rh D 基因分型，以确认和划分基因亚型。
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