Influence of stress-specific interventions on biomarker levels and cognitive function in cancer patients: Systematic review and meta-analysis

IF 3.5 2区心理学 Q1 PSYCHOLOGY, CLINICAL

British Journal of Health Psychology Pub Date : 2024-03-03 DOI:10.1111/bjhp.12716

Xiaotong Ding, Mingyue Zhu, Fang Zhao, Qing Wang, Jiyuan Shi, Zheng Li

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引用次数: 0

Abstract

Purpose

Cancer patients' psycho-physiological health is seriously affected by long-term exposure to stress. Many studies have explored the impact of stress-specific interventions on cancer patients' biomarker levels and cognitive functions. However, the current research findings are inconsistent, and their statistical power is limited by the small samples. Therefore, we conducted this meta-analysis to verify the effect of stress-specific interventions on cancer patients.

Methods

The literature involved nine databases from the inception until January 13, 2024, extracted 19 randomized controlled trials (RCTs). Review Manager (RevMan) 5.4 software was used to perform a meta-analysis, and the revised Cochrane risk of bias tool (RoB2) was utilized for quality evaluation.

Results

Nine RCTs were assessed as having a low risk of bias, and others had a moderate risk. The results showed that stress-specific interventions had beneficial effects on patients' subjective cognition but uncertain impacts on their executive function, tumour necrosis factor-α level, morning cortisol level, and no effect on cortisol at other times, interleukin (IL)-10, IL-8, IL-6, IL-1, and C-reactive protein.

Conclusion

More rigorous studies are required to elucidate the influence of stress-specific interventions on biomarker levels. The potential mechanism by which stress-specific interventions affect the cancer patient's cognitive function remains unclear.

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特定压力干预对癌症患者生物标志物水平和认知功能的影响：系统回顾和荟萃分析。

目的：癌症患者的心理生理健康受到长期压力的严重影响。许多研究探讨了针对压力的干预措施对癌症患者生物标志物水平和认知功能的影响。然而，目前的研究结果并不一致，而且由于样本较少，统计能力也受到限制。因此，我们进行了这项荟萃分析，以验证特定压力干预对癌症患者的影响：文献涉及 9 个数据库，从开始到 2024 年 1 月 13 日，提取了 19 项随机对照试验（RCT）。使用Review Manager（RevMan）5.4软件进行荟萃分析，并使用修订版Cochrane偏倚风险工具（RoB2）进行质量评估：9项研究被评估为低偏倚风险，其他研究为中度偏倚风险。结果表明，针对压力的干预措施对患者的主观认知有好处，但对其执行功能、肿瘤坏死因子-α水平、晨间皮质醇水平的影响不确定，对其他时间的皮质醇、白细胞介素（IL）-10、IL-8、IL-6、IL-1和C反应蛋白没有影响：结论：需要进行更严格的研究，以阐明特定压力干预对生物标志物水平的影响。压力特异性干预对癌症患者认知功能的潜在影响机制仍不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Health Psychology PSYCHOLOGY, CLINICAL-

CiteScore

14.10

自引率

1.30%

发文量

期刊介绍： The focus of the British Journal of Health Psychology is to publish original research on various aspects of psychology that are related to health, health-related behavior, and illness throughout a person's life. The journal specifically seeks articles that are based on health psychology theory or discuss theoretical matters within the field.