Biomarkers of exposure and effect in human biomonitoring of metal-based nanomaterials: their use in primary prevention and health surveillance.

IF 3.6 3区医学 Q3 NANOSCIENCE & NANOTECHNOLOGY

Nanotoxicology Pub Date : 2024-02-01 Epub Date: 2024-03-04 DOI:10.1080/17435390.2023.2301692

Beatrice Bocca, Beatrice Battistini

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引用次数: 0

Abstract

Metal-based nanomaterials (MNMs) have gained particular interest in nanotechnology industry. They are used in various industrial processes, in biomedical applications or to improve functional properties of several consumer products. The widescale use of MNMs in the global consumer market has resulted in increases in the likelihood of exposure and risks to human beings. Human exposure to MNMs and assessment of their potential health effects through the concomitant application of biomarkers of exposure and effect of the most commonly used MNMs were reviewed in this paper. In particular, interactions of MNMs with biological systems and the nanobiomonitoring as a prevention tool to detect the early damage caused by MNMs as well as related topics like the influence of some physicochemical features of MNMs and availability of analytical approaches for MNMs testing in human samples were summarized in this review. The studies collected and discussed seek to increase the current knowledge on the internal dose exposure and health effects of MNMs, highlighting the advantages in using biomarkers in primary prevention and health surveillance.

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金属基纳米材料人体生物监测中的暴露和影响生物标志物：在初级预防和健康监测中的应用。

金属基纳米材料（MNMs）在纳米技术产业中尤其受到关注。它们被用于各种工业流程、生物医学应用或改善一些消费品的功能特性。MNMs 在全球消费市场的广泛使用增加了人类接触 MNMs 的可能性和风险。本文回顾了人类与 MNMs 的接触情况，以及通过同时应用最常用 MNMs 的接触和影响生物标志物来评估其潜在健康影响的情况。本综述特别总结了 MNMs 与生物系统的相互作用、纳米生物监测作为检测 MNMs 所造成早期损害的预防工具，以及 MNMs 某些物理化学特征的影响和人体样本中 MNMs 检测分析方法的可用性等相关主题。所收集和讨论的研究旨在增加目前对 MNMs 体内剂量暴露和健康影响的了解，并强调在初级预防和健康监测中使用生物标记物的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanotoxicology 医学-毒理学

CiteScore

10.10

自引率

4.00%

发文量

审稿时长

3.5 months

期刊介绍： Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.