Familial pancreatic cancer: a long fruitful journey.

IF 1.8 4区医学 Q3 GENETICS & HEREDITY

Familial Cancer Pub Date : 2024-08-01 Epub Date: 2024-03-04 DOI:10.1007/s10689-024-00364-5

Teresa A Brentnall

引用次数: 0

Abstract

In the early years of my GI fellowship, a healthy 40-year-old man came to my clinic and announced that he was going to die of pancreatic cancer. His brothers, father and uncles had all died of the disease; he felt his fate was inescapable. I asked whether his family members had seen doctors or had any tests. His answer was yes to both. Even so, doctors could not diagnose the pancreatic cancer at early stages. CT scans were always negative. I thought to myself, in order to help this patient-CT scans may not be reliable for early detection. Perhaps other methods of imaging the pancreas might be of more benefit. This patient opened a door that led to a 30-year journey of trying to detect pancreatic cancer at earlier stages when it is curable.

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家族性胰腺癌：漫漫征途硕果累累。

在我从事消化道研究的最初几年，一位 40 岁的健康男子来到我的诊所，宣布他将死于胰腺癌。他的兄弟、父亲和叔叔都死于这种疾病；他觉得自己的命运无法逃脱。我问他的家人是否看过医生或做过任何检查。他的回答都是肯定的。即便如此，医生也无法在早期诊断出胰腺癌。CT 扫描结果总是阴性。我心想，为了帮助这位病人，CT 扫描对于早期诊断可能并不可靠。也许其他胰腺成像方法会更有帮助。这位病人打开了一扇门，开启了我 30 年的胰腺癌早期检测之旅。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Familial Cancer 医学-遗传学

CiteScore

4.10

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： In recent years clinical cancer genetics has become increasingly important. Several events, in particular the developments in DNA-based technology, have contributed to this evolution. Clinical cancer genetics has now matured to a medical discipline which is truly multidisciplinary in which clinical and molecular geneticists work together with clinical and medical oncologists as well as with psycho-social workers. Due to the multidisciplinary nature of clinical cancer genetics most papers are currently being published in a wide variety of journals on epidemiology, oncology and genetics. Familial Cancer provides a forum bringing these topics together focusing on the interests and needs of the clinician. The journal mainly concentrates on clinical cancer genetics. Most major areas in the field shall be included, such as epidemiology of familial cancer, molecular analysis and diagnosis, clinical expression, treatment and prevention, counselling and the health economics of familial cancer.