The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology

IF 6.2 2区 生物学 Q1 CELL BIOLOGY
Alice Lacombe , Luca Scorrano
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引用次数: 0

Abstract

The complex relationship between mitochondrial dynamics and autophagy illustrates how two cellular housekeeping processes are intimately linked, illuminating fundamental principles of cellular homeostasis and shedding light on disparate pathological conditions including several neurodegenerative disorders. Here we review the basic tenets of mitochondrial dynamics i.e., the concerted balance between fusion and fission of the organelle, and its interplay with macroautophagy and selective mitochondrial autophagy, also dubbed mitophagy, in the maintenance of mitochondrial quality control and ultimately in cell viability. We illustrate how conditions of altered mitochondrial dynamics reverberate on autophagy and vice versa. Finally, we illustrate how altered interplay between these two key cellular processes participates in the pathogenesis of human disorders affecting multiple organs and systems.

线粒体动力学与自噬之间的相互作用:从关键的平衡机制到病理学的驱动因素
线粒体动力学与自噬之间的复杂关系说明了两个细胞内务过程是如何紧密联系在一起的,阐明了细胞平衡的基本原理,并揭示了包括几种神经退行性疾病在内的不同病理状况。在此,我们回顾了线粒体动力学的基本原理,即细胞器融合与分裂之间的协调平衡,以及线粒体动力学与大自噬和选择性线粒体自噬(也称为丝裂噬)在维持线粒体质量控制和最终维持细胞活力方面的相互作用。我们说明了线粒体动态变化如何对自噬产生影响,反之亦然。最后,我们说明了这两个关键细胞过程之间相互作用的改变是如何参与影响多个器官和系统的人类疾病的发病机制的。
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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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