The role of fibrosis in cardiomyopathies: An opportunity to develop novel biomarkers of disease activity

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology Pub Date : 2024-02-28 DOI:10.1016/j.matbio.2024.02.008

Elisavet Angeli , Maria Jordan , Mandy Otto , Stevan D. Stojanović , Morten Karsdal , Johann Bauersachs , Thomas Thum , Jan Fiedler , Federica Genovese

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引用次数: 0

Abstract

Cardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myocardial stiffness and fibrosis. Additionally, we discuss the potential of ECM fragments as early diagnosis, prognosis, and risk stratification. Biomarkers deriving from turnover of collagens and other ECM proteins hold promise in clinical applications. We outline current clinical management, future directions, and the potential for personalized ECM-targeted therapies with specific focus on microRNAs. In summary, this review examines the role of the fibrosis in cardiomyopathies, highlighting the potential of ECM-derived biomarkers in improving disease management with implications for precision medicine.

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纤维化在心肌病中的作用：开发新的疾病活动生物标志物的契机。

心肌病包括一系列原因和表现各异的心脏疾病。纤维化是各种心肌病的共同特征，反映了其发病机制的共同点。这种普遍的纤维化反应与细胞外基质（ECM）重塑失调的后果有着错综复杂的联系，强调了其在疾病发生和发展过程中的重要性。本综述探讨了 ECM 在各种心肌病中的参与及其对心肌僵化和纤维化的影响。此外，我们还讨论了 ECM 片段作为早期诊断、预后和风险分层的潜力。胶原和其他 ECM 蛋白更替产生的生物标志物在临床应用中大有可为。我们概述了当前的临床管理、未来的发展方向以及个性化 ECM 靶向疗法的潜力，并特别关注 microRNA。总之，本综述探讨了纤维化在心肌病中的作用，强调了 ECM 衍生生物标记物在改善疾病管理方面的潜力，对精准医疗具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Matrix Biology 生物-生化与分子生物学

CiteScore

11.40

自引率

4.30%

发文量

审稿时长

45 days

期刊介绍： Matrix Biology (established in 1980 as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology research. We welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix. Matrix Biology focusses on solving elusive questions, opening new avenues of thought and discovery, and challenging longstanding biological paradigms.