Experimental Study of Autologous Platelet-rich Plasma Combined With Sodium Hyaluronate on Tendon-bone Healing After Rotator Cuff Injury Repair in Rabbits.

IF 1.7 4区医学 Q4 NEUROSCIENCES

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-03-01

Jie Ou, Haobo Wang, Ao Yan, Kunpeng Wang

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引用次数: 0

Abstract

Objective: To investigate the therapeutic effects of autologous platelet-rich plasma (PRP) combined with sodium hyaluronate on tendon healing following rotator cuff injury repair in rabbits.

Methods: New Zealand white rabbits were randomly assigned to five groups: sham operation group, control group, PRP group, sodium hyaluronate group, and combined group, each comprising 12 rabbits. A rotator cuff injury model was established in all groups except the sham operation group. At 8 weeks post-surgery, 12 lateral rotator cuff specimens were taken from each group. Four specimens were randomly selected from each group for biomechanical testing, and analyses were conducted on the expression of vascular endothelial growth factor (VEGF), the fiber area ratio of COL-I and COL-III, and tissue morphology.

Results: The combined group exhibited the highest biomechanical strength in the cuff tissue of white rabbits (P < 0.05). There was no significant difference in VEGF levels among the five groups (F = 0.814, P = 0.523). However, a significant difference was observed in the ratio of fiber area between COL-I and COL-III groups (F = 11.600, P < 0.001), with the combined group scoring the highest (3.82 ± 0.47 minutes). The inflammatory infiltration in tendon-bone tissue was minimal, and histological morphology was optimal.

Conclusion: The combination of PRP and sodium hyaluronate effectively promotes the repair of rotator cuff injuries and accelerates tendon-bone healing.

本刊更多论文

自体富血小板血浆联合透明质酸钠对兔子肩袖损伤修复后肌腱-骨骼愈合的实验研究

目的研究自体富血小板血浆（PRP）联合透明质酸钠对兔子肩袖损伤修复后肌腱愈合的治疗效果：方法：将新西兰白兔随机分为五组：假手术组、对照组、PRP 组、透明质酸钠组和联合组，每组 12 只。除假手术组外，其他各组均建立了肩袖损伤模型。手术后 8 周，每组取 12 个肩袖外侧标本。每组随机抽取 4 个标本进行生物力学测试，并对血管内皮生长因子（VEGF）的表达、COL-I 和 COL-III 的纤维面积比以及组织形态进行分析：结果：联合组白兔袖带组织的生物力学强度最高（P < 0.05）。五组之间的血管内皮生长因子水平无明显差异（F = 0.814，P = 0.523）。然而，COL-I 组和 COL-III 组之间的纤维面积比有明显差异（F = 11.600，P < 0.001），联合组得分最高（3.82 ± 0.47 分）。肌腱骨组织的炎症浸润极少，组织学形态最佳：结论：PRP 和透明质酸钠的组合能有效促进肩袖损伤的修复，并加速肌腱-骨骼的愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of musculoskeletal & neuronal interactions NEUROSCIENCES-PHYSIOLOGY

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Musculoskeletal and Neuronal Interactions (JMNI) is an academic journal dealing with the pathophysiology and treatment of musculoskeletal disorders. It is published quarterly (months of issue March, June, September, December). Its purpose is to publish original, peer-reviewed papers of research and clinical experience in all areas of the musculoskeletal system and its interactions with the nervous system, especially metabolic bone diseases, with particular emphasis on osteoporosis. Additionally, JMNI publishes the Abstracts from the biannual meetings of the International Society of Musculoskeletal and Neuronal Interactions, and hosts Abstracts of other meetings on topics related to the aims and scope of JMNI.