Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis.

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-02-28 DOI:10.1080/21645515.2024.2318815
Yi Huang, Zhijian Chen, Gang Shen, Shuogui Fang, Junjiong Zheng, Zepai Chi, Yuanfeng Zhang, Yitong Zou, Qinghua Gan, Chengxiao Liao, Yuhui Yao, Jianqiu Kong, Xinxiang Fan
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引用次数: 0

Abstract

This study aims to conduct a bibliometric analysis, employing visualization tools to examine literature pertaining to tumor immune evasion related to anti-CTLA-4 and anti-PD-1/PD-L1 therapy from 1999 to 2022. A special emphasis is placed on the interplay between tumor microenvironment, signaling pathways, immune cells and immune evasion, with data sourced from the Web of Science core collection (WoSCC). Advanced tools, including VOSviewer, Citespace, and Scimago Graphica, were utilized to analyze various parameters, such as co-authorship/co-citation patterns, regional contributions, journal preferences, keyword co-occurrences, and significant citation bursts. Out of 4778 publications reviewed, there was a marked increase in research focusing on immune evasion, with bladder cancer being notably prominent. Geographically, China, the USA, and Japan were the leading contributors. Prestigious institutions like MD Anderson Cancer Center, Harvard Medical School, Fudan University, and Sun Yat Sen University emerged as major players. Renowned journals in this domain included Frontiers in Immunology, Cancers, and Frontiers in Oncology. Ehen LP and Wang W were identified as prolific authors on this topic, while Topalian SL stood out as one of the most cited. Research current situation is notably pivoting toward challenges like immunotherapy resistance and the intricate signaling pathways driving drug resistance. This bibliometric study seeks to provide a comprehensive overview of past and current research trends, emphasizing the potential role of tumor microenvironment, signaling pathways and immune cells in the context of immune checkpoint inhibitors (ICIs) and tumor immune evasion.

抗PD-1/PDL-1和抗CTLA-4疗法中的免疫调节和肿瘤微环境对癌症免疫逃避的影响:文献计量分析。
本研究旨在采用可视化工具,对1999年至2022年与抗CTLA-4和抗PD-1/PD-L1疗法相关的肿瘤免疫逃避文献进行文献计量分析。文章特别强调了肿瘤微环境、信号通路、免疫细胞和免疫逃避之间的相互作用,数据来源于科学网核心数据库(WoSCC)。研究人员利用 VOSviewer、Citespace 和 Scimago Graphica 等先进工具分析了各种参数,如合著/合引模式、区域贡献、期刊偏好、关键词共现和重要引文突发。在审查的 4778 篇论文中,以免疫逃避为重点的研究明显增加,其中以膀胱癌最为突出。从地域上看,中国、美国和日本是主要的贡献者。MD 安德森癌症中心、哈佛大学医学院、复旦大学和中山大学等著名机构成为主要参与者。该领域的知名期刊包括《免疫学前沿》、《癌症》和《肿瘤学前沿》。Ehen LP 和 Wang W 被认为是这一主题的多产作者,而 Topalian SL 则是被引用次数最多的作者之一。当前的研究形势正显著转向免疫疗法耐药性和驱动耐药性的复杂信号通路等挑战。这项文献计量学研究旨在全面概述过去和当前的研究趋势,强调肿瘤微环境、信号通路和免疫细胞在免疫检查点抑制剂(ICIs)和肿瘤免疫逃避中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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