Endocardite infectieuse : facteurs prédictifs de mortalité intrahospitalière

IF 0.3 Q4 Medicine

Annales de cardiologie et d'angeiologie Pub Date : 2024-02-27 DOI:10.1016/j.ancard.2024.101740

Othmani Safia , Jendoubi Asma , Hedhli Hana , Jouini Sarra , Zoubli Aymen , Jemai Mouna , Maaref Amal , Ben Kaddour Rym

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引用次数: 0

Abstract

Introduction

Infective endocarditis (IE) remains a serious disease with significant morbidity and mortality despite therapeutic advancements. The aim of our study was to determine the predictive factors of in-hospital mortality.

Patients and methods

A prospective comparative study over a period of 54 months was conducted, including all patients admitted for definite infective endocarditis, diagnosed according to the modified Duke criteria published in 2015 by the European Society of Cardiology.

Results

Thirty-four patients were included. Drug addiction was the main risk factor for infective endocarditis (56%). Tricuspid valve involvement was predominant (50%). Staphylococcus aureus was the most commonly isolated pathogen (65%). In-hospital mortality rate was 47%. In multivariate analysis, predictive factors for mortality were acute heart failure (OR=7.4; p=0.026; 95% CI [1.2–44]) and cerebral embolic localization (OR=11.1; p=0.024; 95% CI [13–90]).

Conclusions

Cardiac and cerebral complications influence the prognosis of IE. Thus, close collaboration among multidisciplinary teams is necessary for improved diagnostic and therapeutic management.

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感染性心内膜炎：预测院内死亡率的因素

导言感染性心内膜炎（IE）是一种严重的疾病，尽管治疗手段不断进步，但发病率和死亡率仍然很高。我们的研究旨在确定院内死亡率的预测因素。患者和方法我们开展了一项为期 54 个月的前瞻性比较研究，研究对象包括所有确诊为感染性心内膜炎的住院患者，诊断标准为欧洲心脏病学会 2015 年发布的修订版杜克标准。吸毒是感染性心内膜炎的主要风险因素（56%）。三尖瓣主要受累（50%）。金黄色葡萄球菌是最常见的分离病原体（65%）。院内死亡率为 47%。在多变量分析中，预测死亡率的因素是急性心力衰竭（OR=7.4；P=0.026；95% CI [1.2-44]）和脑栓塞定位（OR=11.1；P=0.024；95% CI [13-90]）。结论心脑并发症会影响 IE 的预后，因此多学科团队之间必须密切合作，以改善诊断和治疗管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales de cardiologie et d'angeiologie 医学-外周血管病

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Organe scientifique de référence fondé en 1951, les Annales de cardiologie et d''angéiologie abordent tous les domaines qui intéressent quotidiennement les cardiologues et les angéiologues praticiens : neurologie et radiologie vasculaires, hémostase, diabétologie, médecine interne, épidémiologie et prévention. Les Annales de cardiologie et d''angéiologie sont indexées aux grandes bases de données et publient rapidement, et en conformité avec les normes internationales de publication scientifique, des articles en français sur la pathologie cardiaque.