Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation.

IF 2.2 4区医学 Q3 PHARMACOLOGY & PHARMACY

Drugs in Research & Development Pub Date : 2024-03-01 Epub Date: 2024-02-28 DOI:10.1007/s40268-023-00451-5

Sara Rogers, Patrick J Silva, George Udeani, Monica Deleon, Sriarchala Mutyala, Ladan Panahi, Asim Abu-Baker, Gabriel Neal, Kenneth S Ramos

引用次数: 0

Abstract

Background: Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs.

Case: Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy.

Conclusion: SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Supplementary file1 (MP4 8441 KB).

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病例报告：通过药物基因评估发现与氟西汀相关的术后出血危及生命。

背景：选择性血清素再摄取抑制剂（SSRI）常用于治疗抑郁症和焦虑症。抑制血小板中 5-羟色胺的再摄取会增加服用 SSRIs 患者的出血风险。病例：我们在此提供了一例 52 岁患者的病例，该患者在进行泛影葡胺切除术后出现严重的术后出血，需要输血：结论：SSRI 引起的出血与剂量有关，并受到药物代谢酶和转运体个体差异的强烈影响。补充文件1（MP4 8441 KB）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drugs in Research & Development Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Drugs in R&D is an international, peer reviewed, open access, online only journal, and provides timely information from all phases of drug research and development that will inform clinical practice. Healthcare decision makers are thus provided with knowledge about the developing place of a drug in therapy. The Journal includes: Clinical research on new and established drugs; Preclinical research of direct relevance to clinical drug development; Short communications and case study reports that meet the above criteria will also be considered; Reviews may also be considered.