Saira Rafaqat, Dimitrios Patoulias, Amir Hossein Behnoush, Saima Sharif, Aleksandra Klisic
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引用次数: 0
Abstract
Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, and IL-20. The ways to modulate IL activity to reduce inflammation and improve outcomes in individuals with this condition are under investigation. Drugs that target specific ILs might be developed to mitigate the effects of AP.
急性胰腺炎（AP）是一种常见的炎症状态，其临床过程可导致严重的局部和胰腺外器官功能障碍和衰竭。白细胞介素（ILs）是一种具有生物活性的糖蛋白，主要由巨噬细胞和淋巴细胞产生。根据文献记载，白细胞介素有很多种。但本文仅总结了 ILs 在 AP 中的作用，如 IL-1、IL-2、IL-3、IL-4、IL-5、IL-6、IL-7、IL-8、IL-9、IL-10、IL-11、IL-12、IL-13、IL-14、IL-15、IL-16、IL-17、IL-18、IL-19 和 IL-20。目前正在研究如何调节 IL 的活性，以减少炎症并改善患者的预后。针对特定 IL 的药物可能会被开发出来，以减轻 AP 的影响。
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