Efficacy of ornidazole for pericoronitis: a meta-analysis and systematic review.

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2024-01-04 eCollection Date: 2024-01-01 DOI:10.5114/aoms/171907

Ruobing Du, Kai Ba, Yaxin Yang, Yueyue Zhao, Yupeng Lin

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引用次数: 0

Abstract

Introduction: Timely and effective treatments of pericoronitis are very important. We aimed to evaluate the role of ornidazole in the treatment of pericoronitis, to provide insights for clinical pericoronitis treatment.

Material and methods: The PubMed, Clinical trials, EMBASE, Science Direct, Cochrane Library, China National Knowledge Infrastructure (CNKI), Weipu and Wanfang databases were searched to find randomized controlled trials (RCTs) of ornidazole in the treatment of pericoronitis from the establishment of the database to March 15, 2023. Review Manager 5.3 software was used for meta-analysis.

Results: A total of 16 RCTs involving 2004 patients were included. The results of the meta-analysis showed that the effective rate of ornidazole treatment was significantly higher than that of the routine treatment group (RR = 1.22, 95% CI (1.15, 1.29), p < 0.001). Ornidazole treatment was beneficial to reduce the oral bacterial density (MD = -26.13, 95% CI (-32.08, -21.51)), time to pain disappearance (MD = -0.64, 95% CI (-0.92, -0.17)) and time to disappearance of redness and swelling of the teeth crown (MD = -1.45, 95% CI (-2.43, -1.01)) compared to the routine treatment (all p = 0.05). No publication bias was found by the funnel plots and Egger test (p = 0.206).

Conclusions: Ornidazole is effective in the treatment of pericoronitis, with more advantages. Still, the effects and safety of ornidazole in the treatment of pericoronitis need to be evaluated by more high-quality RCTs with larger sample sizes.

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奥硝唑治疗冠周炎的疗效：一项荟萃分析和系统综述。

导言及时有效地治疗冠周炎非常重要。我们旨在评估奥硝唑在治疗冠周炎中的作用，为临床冠周炎治疗提供启示：检索PubMed、Clinical trials、EMBASE、Science Direct、Cochrane Library、中国知网（CNKI）、微普、万方等数据库，寻找自数据库建立至2023年3月15日期间奥硝唑治疗冠周炎的随机对照试验（RCT）。使用Review Manager 5.3软件进行荟萃分析：结果：共纳入了 16 项 RCT，涉及 2004 名患者。荟萃分析结果显示，奥硝唑治疗组的有效率明显高于常规治疗组（RR = 1.22，95% CI (1.15, 1.29)，P < 0.001）。与常规治疗相比，奥硝唑治疗有利于降低口腔细菌密度（MD = -26.13，95% CI (-32.08, -21.51)）、疼痛消失时间（MD = -0.64，95% CI (-0.92, -0.17)）和牙冠红肿消失时间（MD = -1.45, 95% CI (-2.43, -1.01) ）（均为 p = 0.05）。通过漏斗图和Egger检验（P = 0.206），未发现发表偏倚：结论：奥硝唑治疗冠周炎效果显著，优势较多。尽管如此，奥硝唑治疗冠周炎的效果和安全性仍需更多样本量更大的高质量 RCT 进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.