P- 56 TUBERCULOSIS IN LIVER TRANSPLANT RECIPIENTS: EXPERIENCE OF A SINGLE CENTER

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2024-02-01 DOI:10.1016/j.aohep.2023.101243

Cárdenas Ramírez Bertha , Padilla-Machaca P. Martin , Cerrón Cabezas Carmen

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引用次数: 0

Abstract

Introduction and Objectives

In Peru the tuberculosis (TB) is an endemic infectious disease. This disease is a serious opportunistic infection in transplant recipients (LTRs) and has 20 to 74-fold increase in a chance of developing compared to the general population The prevalence of TB in (LTRs) is variable between regions. This study aims to describe the rate, clinics characteristics and mortality of TB in LTRs from a high-prevalence area.

Materials and Methods

We conducted a retrospective review of liver transplant recipients with tuberculosis diagnoses at Guillermo Almenara Hospital between Mach 2001 and March 2022.

Results

A total of 294 patients underwent LT during this period. 7 (2.3 %) adult patients were diagnosed with active TB. Mean age was 49 (32- 64) years; 5 (70 %) were males. Time interval from LT to TB diagnosis was 57 months (2-136) and 42 % had early tuberculosis (< 12 m). Three patients had disseminated TB and Four pulmonary involvement. 72 % received individualized treatment to avoid hepatotoxicity related to treatment, 28.5% had DILI with standard treatment. We found 28.5 % mortality no related to TB infections.

Conclusions

We observed a low rate of TB in LTRs (2.3%) from a high prevalence region. Most of our patients received individualized treatment.

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P- 56 肝移植受者的结核病：单个中心的经验

导言和目标在秘鲁，结核病（TB）是一种地方性传染病。肺结核是移植受者（LTRs）中的一种严重机会性感染，与普通人群相比，其发病几率增加了 20 到 74 倍。本研究旨在描述来自高发地区的肝移植受者中结核病的发病率、临床特征和死亡率。材料和方法我们对 2001 年马赫至 2022 年 3 月期间在吉列尔莫-阿尔梅纳拉医院确诊为结核病的肝移植受者进行了回顾性审查。7名（2.3%）成年患者被诊断为活动性肺结核。平均年龄为 49（32-64）岁；男性 5 人（70%）。从接受肺结核治疗到确诊肺结核的时间间隔为 57 个月（2-136），42% 的患者患有早期肺结核（12 个月）。三名患者为播散性肺结核，四名患者为肺部受累。72%的患者接受了个体化治疗，以避免与治疗相关的肝脏毒性，28.5%的患者在接受标准治疗后出现了肝脏损害。我们发现 28.5% 的死亡率与肺结核感染无关。我们的大多数患者都接受了个性化治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.