Epigenetics, Bone Remodeling and Osteoporosis.

Current stem cell research & therapy Pub Date : 2016-12-21
Shaoqing Yang, Xiaohong Duan
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Abstract

Epigenetic regulation, including modifications of DNA, histone proteins and non-coding RNAs, play an important role in the regulation of gene expression and keep the heritable traits of progeny cells without changing DNA sequence. Recent years, epigenetic regulation of bone homeostasis are widely investigated and considered as a vital factor during the differentiation and function of osteoblasts, osteoclasts and osteocytes. Osteoporosis is a common degenerative bone disease which is characterized with decreased bone strength and increased risk of fracture. It has been testified that the abnormal bone metabolism homeostasis, especially in osteoclast function, take a fundamental role in osteoporosis pathogenesis. The reports between osteoporosis and epigenetic regulations are also increased gradually in recent years. In this review, we summarize the current developments of epigenetic regulation mechanism in bone development and remodeling, and emphasize the epigenetic features of osteoporosis and the potent therapy application of epigenetic drugs for osteoporosis.

表观遗传学、骨重塑和骨质疏松症。
表观遗传调控包括 DNA、组蛋白和非编码 RNA 的修饰,在调控基因表达和保持后代细胞遗传性状方面发挥着重要作用,而无需改变 DNA 序列。近年来,骨稳态的表观遗传调控被广泛研究,并被认为是成骨细胞、破骨细胞和骨细胞分化和功能发挥过程中的重要因素。骨质疏松症是一种常见的退行性骨病,其特点是骨强度降低和骨折风险增加。有研究证实,骨代谢平衡异常,尤其是破骨细胞功能异常,在骨质疏松症的发病机制中起着根本性的作用。近年来,关于骨质疏松症与表观遗传调控之间关系的报道也逐渐增多。在这篇综述中,我们总结了骨发育和重塑过程中表观遗传调控机制的最新进展,并强调了骨质疏松症的表观遗传学特征以及表观遗传药物在骨质疏松症中的有效治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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