Characteristics of ADHD Symptoms and EEG Theta/Beta Ratio in Children With Sleep Disordered Breathing.

Clinical EEG and neuroscience Pub Date : 2024-07-01 Epub Date: 2024-02-25 DOI:10.1177/15500594241234828
Dandi Ma, Yunxiao Wu, Changming Wang, Fujun Zhao, Zhifei Xu, Xin Ni
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Abstract

Objectives. This study aimed to explore parent-reported symptoms of attention deficit-hyperactivity disorder (ADHD) and sleep electroencephalogram (EEG) theta/beta ratio (TBR) characteristics in children with sleep disordered breathing (SDB). Methods. The parents of children (aged 6-11 years) with SDB (n = 103) and healthy controls (n = 28) completed the SNAP-IV questionnaire, and children underwent overnight polysomnography. Children with SDB were grouped according to obstructive apnea/hypopnea index: primary snoring, mild, and moderate-severe obstructive sleep apnea (OSA) groups. The TBR in non-rapid eye movement (NREM) periods in three sleep cycles was analyzed. Results. Children with SDB showed worse ADHD symptoms compared with the healthy control. There was no intergroup difference in TBR. The time-related decline in TBR observed in the control, primary snoring and mild OSA groups, which was not observed in the moderate-severe OSA group. Overnight transcutaneous oxygen saturation was negatively associated with the hyperactivity/impulsivity score of ADHD symptom. The global TBR during the NREM period in the first sleep cycle was positively correlated with inattention score. Conclusion. Children with SDB showed more ADHD inattention symptoms than the healthy control. Although we found no difference in TBR among groups, we found significant main effect for NREM period. There existed a relationship between hypoxia, TBR, and scores of ADHD symptoms. Hence, it was speculated that TBR can reflect the nocturnal electrophysiological manifestations in children with SDB, which may be related to daytime ADHD symptoms.

睡眠呼吸障碍儿童的多动症症状特征和脑电图 Theta/Beta 比率。
研究目的本研究旨在探讨睡眠呼吸障碍(SDB)儿童中家长报告的注意力缺陷多动障碍(ADHD)症状和睡眠脑电图(EEG)θ/β比值(TBR)特征。研究方法患有睡眠呼吸障碍(SDB)的儿童(6-11 岁)(103 人)和健康对照组(28 人)的父母填写了 SNAP-IV 问卷,儿童接受了夜间多导睡眠图检查。根据阻塞性呼吸暂停/低通气指数对患有 SDB 的儿童进行分组:原发性打鼾组、轻度组和中重度阻塞性睡眠呼吸暂停(OSA)组。分析了三个睡眠周期非快速眼动(NREM)期的TBR。结果显示与健康对照组相比,患有 SDB 的儿童表现出更严重的多动症状。各组间的 TBR 没有差异。在对照组、原发性打鼾组和轻度 OSA 组观察到与时间相关的 TBR 下降,而在中重度 OSA 组未观察到。隔夜经皮血氧饱和度与多动症症状的多动/冲动评分呈负相关。第一个睡眠周期 NREM 期间的总体 TBR 与注意力不集中评分呈正相关。结论与健康对照组相比,SDB患儿表现出更多的ADHD注意力不集中症状。虽然我们发现各组之间的 TBR 没有差异,但我们发现 NREM 期间有显著的主效应。缺氧、TBR 和 ADHD 症状得分之间存在关系。因此,我们推测 TBR 可以反映 SDB 儿童的夜间电生理表现,而夜间电生理表现可能与白天的 ADHD 症状有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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