Exploring the latency period in Chagas disease: duration and determinants in a cohort from Colombia.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-05 DOI:10.1093/trstmh/trae004

Mario Javier Olivera, Lyda Muñoz

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Abstract

Background: Chagas disease has a varying latency period, the time between infection and onset of cardiac symptoms, due to multiple factors. This study seeks to identify and understand these factors to enhance our knowledge of the disease.

Methods: A retrospective follow-up study was conducted in Colombia on patients with indeterminate chronic Chagas disease. Medical files were examined to evaluate the disease latency time using time ratios (TRs) and the AFT Weibull model.

Results: The study followed 578 patients, of whom 309 (53.5%) developed cardiac disease, with a median latency period of 18.5 (95% CI 16 to 20) y for the cohort. Those with the TcISyl genotype (TR 0.72; 95% CI 0.61 to 0.80), individuals who lived 5-15 y (TR 0.80; 95% CI 0.67 to 0.95), 15-30 y (TR 0.63; 95% CI 0.53 to 0.74) or >30 y (vs 5 y) in areas with high disease prevalence had shorter latency periods. On the other hand, undergoing treatment increased the latency period (TR: 1.74; 95% CI 1.52 to 1.87).

Conclusions: The latency period of Chagas disease was found to be independently related to male gender, receipt of etiological treatment, length of time spent in an endemic area and the TcISyl genotype. The implications of these findings are discussed.

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探索南美锥虫病的潜伏期：哥伦比亚队列中的潜伏期和决定因素。

背景：南美锥虫病的潜伏期（从感染到出现心脏症状的时间）因多种因素而异。本研究旨在确定和了解这些因素，以增进我们对该疾病的了解：方法：在哥伦比亚对不确定的慢性南美锥虫病患者进行了一项回顾性随访研究。研究采用时间比率（TRs）和AFT Weibull模型对医疗档案进行检查，以评估疾病的潜伏时间：该研究跟踪了 578 名患者，其中 309 人（53.5%）罹患心脏疾病，中位潜伏期为 18.5 年（95% CI 16-20 年）。那些具有TcISyl基因型（TR 0.72；95% CI 0.61至0.80）、在疾病高发地区生活了5至15年（TR 0.80；95% CI 0.67至0.95）、15至30年（TR 0.63；95% CI 0.53至0.74）或超过30年（vs 5年）的人的潜伏期较短。另一方面，接受治疗会延长潜伏期（TR：1.74；95% CI 1.52 至 1.87）：结论：研究发现恰加斯病的潜伏期与男性性别、接受病因治疗的时间、在流行地区居住的时间和 TcISyl 基因型无关。本文讨论了这些发现的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.