Growth performance, lipid metabolism, and systemic immunity of weaned piglets were altered by buckwheat protein through the modulation of gut microbiota.

IF 2.3 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Genetics and Genomics Pub Date : 2024-02-27 DOI:10.1007/s00438-024-02103-y

Weilong Tu, Wansen Nie, Xiaohui Yao, Junjie Zhang, Hailong Zhang, Di Di, Zongjie Li

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Abstract

Tartary buckwheat protein (BWP) is well known for the wide-spectrum antibacterial activity and the lipid metabolism- regulating property; therefore, BWP can be applied as feed additives to improve the animal's nutritional supply. With the aim to investigate the bioactive actions of the BWP, growth performance, lipid metabolism and systemic immunity of the weaned piglets were measured, and the alterations of pig gut microbiota were also analyzed. According to the results, the growth performances of the weaned piglets which were calculated as the average daily gain (ADG) and the average daily feed intake (ADFI) were significantly increased when compared to the control group. Simultaneously, the serum levels of the total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were decreased, while the levels of high-density lipoprotein cholesterol (HDL-C) were increased in the BWP group. Moreover, the relative abundances of Lactobacillus, Prevotella_9, Subdoligranulum, Blautia, and other potential probiotics in the gut microbiota of weaned piglets were obviously increased in the BWP group. However, the relative abundances of Escherichia-Shigella, Campylobacter, Rikenellaceae_RC9_gut_group and other opportunistic pathogens were obviously decreased in the BWP group. In all, BWP was proved to be able to significantly improve the growth performance, lipid metabolism, and systemic immunity of the weaned piglets, and the specific mechanism might relate to the alterations of the gut microbiota. Therefore, BWP could be explored as a prospective antibiotic alternative for pig feed additives.

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荞麦蛋白通过调节肠道微生物群来改变断奶仔猪的生长性能、脂代谢和全身免疫力。

众所周知，鞑靼荞麦蛋白（BWP）具有广谱抗菌活性和调节脂质代谢的特性，因此可作为饲料添加剂改善动物的营养供给。为了研究 BWP 的生物活性作用，研究人员测定了断奶仔猪的生长性能、脂代谢和全身免疫力，并分析了猪肠道微生物群的变化。结果表明，与对照组相比，断奶仔猪的生长性能（以平均日增重和平均日采食量计算）显著提高。同时，BWP 组的血清总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平降低，而高密度脂蛋白胆固醇（HDL-C）水平升高。此外，断奶仔猪肠道微生物群中乳酸杆菌、普雷沃特氏菌_9、亚多球菌、布劳氏菌等潜在益生菌的相对丰度在 BWP 组明显增加。但 BWP 组断奶仔猪肠道微生物群中的志贺氏菌、弯曲杆菌、Rikenellaceae_RC9_gut_group 和其他机会致病菌的相对丰度明显降低。总之，BWP 能显著提高断奶仔猪的生长性能、脂代谢和全身免疫力，其具体机制可能与肠道微生物群的改变有关。因此，BWP 可作为猪饲料添加剂的一种抗生素替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Genetics and Genomics 生物-生化与分子生物学

CiteScore

5.10

自引率

3.20%

发文量

134

审稿时长

1 months

期刊介绍： Molecular Genetics and Genomics (MGG) publishes peer-reviewed articles covering all areas of genetics and genomics. Any approach to the study of genes and genomes is considered, be it experimental, theoretical or synthetic. MGG publishes research on all organisms that is of broad interest to those working in the fields of genetics, genomics, biology, medicine and biotechnology. The journal investigates a broad range of topics, including these from recent issues: mechanisms for extending longevity in a variety of organisms; screening of yeast metal homeostasis genes involved in mitochondrial functions; molecular mapping of cultivar-specific avirulence genes in the rice blast fungus and more.