Association of the interleukine-6 polymorphism with catheter-induced coronary artery spasm in Egyptians.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2024-06-01 Epub Date: 2024-02-20 DOI:10.1097/MCA.0000000000001340

Tarek A Abdelaziz, Randa H Mohamed, Ashraf A Dwedar, Mohey Eldeen A Eldeeb, Abdelrahman A Abdelfattah, Sara F Saadawy

{"title":"Association of the interleukine-6 polymorphism with catheter-induced coronary artery spasm in Egyptians.","authors":"Tarek A Abdelaziz, Randa H Mohamed, Ashraf A Dwedar, Mohey Eldeen A Eldeeb, Abdelrahman A Abdelfattah, Sara F Saadawy","doi":"10.1097/MCA.0000000000001340","DOIUrl":null,"url":null,"abstract":"Background: The role of coronary artery spasm (CAS) was extended beyond variant angina to ischemic heart disease in general, including effort angina, unstable angina, acute myocardial infarction (MI) and sudden death. It is difficult and cumbersome to examine CAS during coronary angiography. Risk factors for CAS include smoking and genetic polymorphisms.Aim: We aimed to investigate the association of the interleukin-6 (IL-6) polymorphism with catheter-induced CAS in Egyptian patients who undergo coronary angiography.Methods: This is a case-control study. Two hundred patients with chronic coronary artery disease who underwent elective coronary angiography were included in the study. Patients were divided into two groups: the non-CAS group (100 patients) and the CAS group (100 patients). The subjects were genotyped to the -572 C>G (rs 1800796) polymorphism of the IL-6 gene by PCR-restriction fragment length polymorphism.Results: We found that patients with CAS have more risk factors for atherosclerosis compared to those without CAS. Smoking, the IL-6 GG genotype, and the G allele were independent risk factors for CAS.Conclusion: We concluded that the GG genotype and G allele of the IL-6 gene are associated with CAS. Smoking, the GG genotype, and the G allele of the IL-6 gene are independent predictors of catheter-induced CAS.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"309-313"},"PeriodicalIF":1.5000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronary artery disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MCA.0000000000001340","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The role of coronary artery spasm (CAS) was extended beyond variant angina to ischemic heart disease in general, including effort angina, unstable angina, acute myocardial infarction (MI) and sudden death. It is difficult and cumbersome to examine CAS during coronary angiography. Risk factors for CAS include smoking and genetic polymorphisms.

Aim: We aimed to investigate the association of the interleukin-6 (IL-6) polymorphism with catheter-induced CAS in Egyptian patients who undergo coronary angiography.

Methods: This is a case-control study. Two hundred patients with chronic coronary artery disease who underwent elective coronary angiography were included in the study. Patients were divided into two groups: the non-CAS group (100 patients) and the CAS group (100 patients). The subjects were genotyped to the -572 C>G (rs 1800796) polymorphism of the IL-6 gene by PCR-restriction fragment length polymorphism.

Results: We found that patients with CAS have more risk factors for atherosclerosis compared to those without CAS. Smoking, the IL-6 GG genotype, and the G allele were independent risk factors for CAS.

Conclusion: We concluded that the GG genotype and G allele of the IL-6 gene are associated with CAS. Smoking, the GG genotype, and the G allele of the IL-6 gene are independent predictors of catheter-induced CAS.

查看原文本刊更多论文

埃及人白细胞介素-6多态性与导管诱发冠状动脉痉挛的关系

背景：冠状动脉痉挛（CAS）的作用已从变异型心绞痛扩展到一般缺血性心脏病，包括劳力性心绞痛、不稳定性心绞痛、急性心肌梗死（MI）和猝死。在冠状动脉造影术中检查 CAS 既困难又麻烦。CAS的危险因素包括吸烟和基因多态性。目的：我们旨在研究接受冠状动脉造影术的埃及患者中白细胞介素-6（IL-6）多态性与导管诱发CAS的关系：这是一项病例对照研究。方法：这是一项病例对照研究。研究纳入了 200 名接受择期冠状动脉造影术的慢性冠状动脉疾病患者。患者分为两组：非 CAS 组（100 名患者）和 CAS 组（100 名患者）。受试者通过PCR-限制性片段长度多态性对IL-6基因的-572 C>G（rs 1800796）多态性进行基因分型：我们发现，与无 CAS 的患者相比，CAS 患者有更多动脉粥样硬化的危险因素。吸烟、IL-6 GG 基因型和 G 等位基因是 CAS 的独立危险因素：我们得出结论：IL-6基因的GG基因型和G等位基因与CAS有关。吸烟、IL-6 基因的 GG 基因型和 G 等位基因是导管诱发 CAS 的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.