Constituents from the Polar Extract of Pisolithus arhizus and Their Anti-inflammatory Activity

IF 3.6 2区 生物学 Q2 CHEMISTRY, MEDICINAL
Valentina Parisi, Raffaella Nocera, Emanuele Rosa, Valeria Iobbi, Samad Nejad Ebrahimi, Alessandra Braca, Nunziatina De Tommasi* and Giuliana Donadio, 
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引用次数: 0

Abstract

The phytochemical study of the Pisolithus arhizus fruiting body methanol extract led to the isolation of six new triterpenoids (16) and one new naphthalenoid pulvinic acid derivative (7), together with five known compounds, including norbadione A (8). Their structure was established from 1D and 2D NMR spectroscopy and HRESIMS analyses. The absolute configuration of the triterpenoids was determined by circular dichroism. The two pulvinic acid derivatives 7 and 8, showing the highest activity in modulating IL-6 secretion, were tested for their effect on COX-2, STAT3, and p-STAT3 proteins; both compounds were able to downregulate p-STAT3.

Abstract Image

Abstract Image

鸢尾属植物极性提取物中的成分及其抗炎活性
通过对 Pisolithus arhizus 子实体甲醇提取物的植物化学研究,分离出了六种新的三萜类化合物(1-6)和一种新的萘类药物普鲁文酸衍生物(7),以及五种已知化合物,包括去甲斑蝥素 A(8)。这些化合物的结构是通过一维和二维核磁共振光谱以及 HRESIMS 分析确定的。三萜类化合物的绝对构型是通过圆二色性测定的。在调节 IL-6 分泌方面表现出最高活性的两种蒲公英酸衍生物 7 和 8 被检测了对 COX-2、STAT3 和 p-STAT3 蛋白的影响;这两种化合物都能下调 p-STAT3 蛋白。
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍: The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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